ResearchWorks Archive
    • Login
    View Item 
    •   ResearchWorks Home
    • Dissertations and Theses
    • Bioengineering
    • View Item
    •   ResearchWorks Home
    • Dissertations and Theses
    • Bioengineering
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Tissue-Engineered Arterial Tunica Media with Multi-layered, Circumferentially Aligned Smooth Muscle Architecture

    Thumbnail
    View/Open
    Yan_washington_0250O_18985.pdf (2.668Mb)
    Author
    Yan, Shi Ying Calysta
    Metadata
    Show full item record
    Abstract
    Blood vessels play an important role in drug screening in terms of permeability and control of blood flow through cellular responses. Three distinctive functional layers make up the architecture of blood vessels, including tunica intima, tunica media and tunica externa. Among all layers, the tunica media layer regulates vascular tone and circumferential alignment of smooth muscle cells in tunica media is crucial to constrictive performances of vessels. Although much research has studied the anisotropic alignment of smooth muscle cells, there is yet a method to fabricate anisotropic smooth muscle cells in a three-dimensional hydrogel to mimic native tunica media. This project addresses the need for an in vitro tissue-engineered tunica media model that replicates in vivo architecture of circumferentially aligned smooth muscle cells in tunica media that is robust and reproducible. The project is divided into three phases: (1) A robust method to fabricate three-dimensional tunica media with circumferentially aligned smooth muscle cells and (2) the characterization and assessment on functional properties of tunica media model. Ultimately, the success of this project allows formation of tunica media with native functionalities through cellular remodeling and mechanical properties to serve as a model of tunica media tissue in blood vessels.
    URI
    http://hdl.handle.net/1773/42204
    Collections
    • Bioengineering [241]

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    @mire NV
     

     

    Browse

    All of ResearchWorksCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2015  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    @mire NV