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dc.contributor.advisorJiang, Shaoyi
dc.contributor.authorMa, Jinrong
dc.date.accessioned2018-07-31T21:10:16Z
dc.date.submitted2018
dc.identifier.otherMa_washington_0250O_18413.pdf
dc.identifier.urihttp://hdl.handle.net/1773/42230
dc.descriptionThesis (Master's)--University of Washington, 2018
dc.description.abstractZwitterionic materials have been demonstrated to have excellent non-fouling properties for a wide range of biomedical and engineering applications. Inspired by naturally occurring osmolytes, our group have developed new zwitterionic molecules. In this work, one of these new zwitterionic materials has been studied for its non-fouling properties when it is coated on a surface via atom transfer radical polymerization (ATRP) and prepared as a hydrogel and for its ability to protect proteins when it is conjugated to a highly immunogenic protein such as uricase. Results are compared with those from poly(ethylene glycol) (PEG) and other zwitterionic materials whenever possible. Results show that this new material based on a naturally occurring osmolyte is able to effectively prevent non-specific protein adsorption and to maintain protein stability and stability.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.rightsnone
dc.subject704100
dc.subjectChemical engineering
dc.subject.otherChemical engineering
dc.titleStudy of a Novel Zwitterionic Material and Its Biological Applications
dc.typeThesis
dc.embargo.termsDelay release for 1 year -- then make Open Access
dc.embargo.lift2019-07-31T21:10:16Z


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