Center for Research in Reproduction and Contraception
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The Center for Research in Reproduction and Contraception at the University of Washington is dedicated to basic and clinical research focused primarily on the male reproductive system. Under the auspices of the Center, fifteen project investigators are working to understand the biology of this complex system and to apply their findings to problems of infertility and contraceptive development. Their research ranges from the biophysics of cell signaling to clinical trials of hormonal contraceptives. Other important goals are to train young scientists in the methods of reproductive biology and medicine and to maintain cooperative research with institutions in developing countries. Together, the scientists and trainees of the CRRC are addressing some of the most challenging scientific problems as well as the most pressing social issues of our time.
Recent Submissions
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Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse
(Endocrine Society, 2001-12)Galanin-like peptide (GALP) is a newly discovered molecule whose expression in the brain is confined to the arcuate nucleus and median eminence. In the rat, cellular levels of GALP mRNA are reduced by fasting ... -
Male hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese men
(American Society of Andrology, 2004-09)Monthly injections of testosterone undecanoate (TU) act as a male contraceptive by reversibly suppressing spermatogenesis to azoospermia or severe oligoazoospermia in 95% of Chinese men. In 5% of Chinese ... -
Serum inhibin concentrations before and during gonadotropin treatment in men with hypogonadotropic hypogonadism: physiological and clinical implications
(Endocrine Society, 1990-05)We measured by RIA the inhibin concentrations in the sera of 20 men with hypogonadotropic hypogonadism before and during treatment with gonadotropins in order to determine the role of gonadotropins in the ... -
Novel male hormonal contraceptive combinations: the hormonal and spermatogenic effects of testosterone and levonorgestrel combined with a 5alpha-reductase inhibitor or gonadotropin-releasing hormone antagonist
(Endocrine Society, 2005-01)We postulated that the addition of a combined types I and II, 5alpha-reductase inhibitor (dutasteride) or long-acting GnRH antagonist (acyline) to combination testosterone plus levonorgestrel treatment may be advantageous ... -
Clusterin in the male reproductive system: localization and possible function
(Elsevier, 1999-05-25)Clusterin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic ... -
Colchicine and testicular function in man
(Massachusetts Medical Society, 1976-06-17) -
Testosterone replacement in hypogonadal men: effects on obstructive sleep apnoea, respiratory drives, and sleep
(Blackwell Publishing, 1985-06)The obstructive sleep apnoea syndrome occurs predominantly in men. To determine the effect of testosterone on ventilatory function and whether testosterone may play a role in the development of obstructive ... -
The physiological significance of pulsatile LHRH secretion in man: gonadotrophin responses to physiological doses of pulsatile versus continuous LHRH administration
(Blackwell Publishing, 1991-02)This study tested whether pulsatile LHRH stimulation of the pituitary is required for normal gonadotrophin secretion in man. Four men with idiopathic hypogonadotrophic hypogonadism (IHH) and presumed endogenous ... -
Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat
(Endocrine Society, 1993-04)Galanin is colocalized with GnRH in neurons of the hypothalamus and basal forebrain of female rats, and this neuropeptide may play a role in the generation of the midcycle surge of gonadotropin secretion. We ... -
Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women
(Endocrine Society, 1996-03)Women experience a decline in fertility that precedes the menopause by several years. Previous studies have demonstrated a monotropic rise in FSH associated with reproductive aging: however, the mechanism of ... -
Differential control of luteinizing hormone and follicle-stimulating hormone secretion by luteinizing hormone-releasing hormone pulse frequency in man
(Endocrine Society, 1987-04)To test the hypothesis that the frequency of pulsatile LHRH stimulation can differentially control LH and FSH secretion in man, we administered low doses of LHRH in pulsatile fashion in several different ... -
Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study
(Endocrine Society, 2002-02)We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and ... -
Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules
(Rockefeller University Press, 1995-05)Previous studies in transgenic mice have established the importance of the 3' untranslated region (UTR) of the spermatid-specific protamine-1 (Prm-1) mRNA in its translational control during male germ cell ... -
Age-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women
(Endocrine Society, 2004-06)Previous studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found ... -
Elevated serum follicle-stimulating hormone levels in men with normal seminal fluid analyses
(Elsevier, 1983-03)Three men who volunteered as normal subjects were found to have abnormally high levels of serum follicle-stimulating hormone (FSH) despite having normal seminal fluid analyses and fertility. Two of the men ... -
Leptin is a metabolic signal to the reproductive system
(Endocrine Society, 1996-07)Leptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin ... -
An automated technique for the radiographic determination of bone age
(Blackwell Publishing, 1982)We have developed an automated procedure for determining bone-age in the monkey, Macaca fascicularis. The status of epiphysial junctions and sesamoids were determined from radiographs. Epiphyses were scored ... -
Molecular genetic analysis of mammalian spermatid differentiation
(Endocrine Society, 1995) -
Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens
(Endocrine Society, 1994-09)Androgens are essential for the maintenance of normal spermatogenesis in the rat. We assessed the sites, developmental pattern, and hormonal control of androgen receptors (AR) in the rat testis. Adult male ...