Now showing items 1-5 of 5

    • Distribution of galanin messenger RNA-expressing cells in murine brain and their regulation by leptin in regions of the hypothalamus 

      Clifton, Donald K.; Steiner, Robert A.; Hohmann, John G.; Cheung, Clement C. (Elsevier, 2001)
      Galanin is widely distributed throughout the mammalian brain and has been implicated in the regulation of food intake, metabolism and reproduction-functions that are also thought to be under the control of ...
    • Leptin is a metabolic gate for the onset of puberty in the female rat 

      Weigle, David S.; Kuijper, Joseph L.; Steiner, Robert A.; Clifton, Donald K.; Cheung, Clement C.; Thornton, Janice E. (Endocrine Society, 1997-02)
      The timing of puberty onset in mammals is tightly coupled to the animal's nutritional and metabolic state. We conducted two experiments to test the hypothesis that leptin acts as a metabolic signal for the ...
    • Leptin is a metabolic signal to the reproductive system 

      Ren, Hongping; Clifton, Donald K.; Weigle, David S.; Steiner, Robert A.; Kuijper, Joseph L.; Kabigting, Emilia B.; Barash, Ilona A.; Cheung, Clement C. (Endocrine Society, 1996-07)
      Leptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin ...
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus 

      Steiner, Robert A.; Cheung, Clement C.; Clifton, Donald K. (Endocrine Society, 1997-10)
      Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic ...
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice 

      Steiner, Robert A.; Clifton, Donald K.; Thornton, Janice E.; Cheung, Clement C. (Endocrine Society, 1997-11)
      The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which ...