Now showing items 1-6 of 6

    • Effect of fasting, refeeding, and dietary fat restriction on plasma leptin levels 

      Steiner, Robert A.; Connor, William E.; Kuijper, Joseph L.; Soules, Michael R.; Weigle, David S.; Duell, P. Barton (Endocrine Society, 1997-02)
      The factors responsible for the variability in plasma leptin levels observed among individuals with similar body compositions remain unclear. To examine the impact of dietary variables, we compared the changes ...
    • Leptin is a metabolic gate for the onset of puberty in the female rat 

      Weigle, David S.; Kuijper, Joseph L.; Steiner, Robert A.; Clifton, Donald K.; Cheung, Clement C.; Thornton, Janice E. (Endocrine Society, 1997-02)
      The timing of puberty onset in mammals is tightly coupled to the animal's nutritional and metabolic state. We conducted two experiments to test the hypothesis that leptin acts as a metabolic signal for the ...
    • Leptin is a metabolic signal to the reproductive system 

      Ren, Hongping; Clifton, Donald K.; Weigle, David S.; Steiner, Robert A.; Kuijper, Joseph L.; Kabigting, Emilia B.; Barash, Ilona A.; Cheung, Clement C. (Endocrine Society, 1996-07)
      Leptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin ...
    • Lords and ladies leapin' on leptin [editorial; comment] 

      Steiner, Robert A. (Endocrine Society, 1996-11)
    • Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus 

      Steiner, Robert A.; Cheung, Clement C.; Clifton, Donald K. (Endocrine Society, 1997-10)
      Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic ...
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice 

      Steiner, Robert A.; Clifton, Donald K.; Thornton, Janice E.; Cheung, Clement C. (Endocrine Society, 1997-11)
      The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which ...