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Browsing Center for Research in Reproduction and Contraception by Subject "RNA, Messenger, metabolism"
Now showing items 1-17 of 17
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Activation of the sympathetic nervous system by galanin-like peptide--a possible link between leptin and metabolism
(Endocrine Society, 2003-11)The effects of leptin upon body weight (BW) cannot be explained by its anorectic actions alone. Part of the metabolic changes elicited by leptin includes sympathetic nervous system activation leading to ... -
Activation-dependent regulation of galanin gene expression in gonadotropin-releasing hormone neurons in the female rat [see comments]
(Endocrine Society, 1994-05)In rats, galanin is colocalized in GnRH neurons, and galanin mRNA in GnRH neurons is increased coincidentally with the preovulatory gonadotropin surge. Whether the induction of galanin mRNA in GnRH neurons ... -
Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse
(Endocrine Society, 2005-07)Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor. Kisspeptins and GPR54 have been implicated in the neuroendocrine regulation of GnRH secretion. To test the ... -
Distribution and regulation of galanin-like peptide (GALP) in the hypothalamus of the mouse
(Endocrine Society, 2001-12)Galanin-like peptide (GALP) is a newly discovered molecule whose expression in the brain is confined to the arcuate nucleus and median eminence. In the rat, cellular levels of GALP mRNA are reduced by fasting ... -
Ectopic galanin expression and normal galanin receptor 2 and galanin receptor 3 mRNA levels in the forebrain of galanin transgenic mice
(Elsevier, 2005)The functional interactions of the neuropeptide galanin (GAL) occur through its binding to three G protein-coupled receptor subtypes: galanin receptor (GALR) 1, GALR2 and GALR3. Previously, we demonstrated ... -
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat
(Endocrine Society, 2000-07)Galanin-like peptide (GALP), which was recently isolated from the porcine hypothalamus, shares sequence homology with galanin and binds with high affinity to galanin receptors. To study the distribution and ... -
Galanin-like peptide as a possible link between metabolism and reproduction in the macaque
(Endocrine Society, 2004-04)Galanin-like peptide (GALP) is a hypothalamic neuropeptide that has been implicated in the control of feeding, metabolism, and reproduction. The goal of this study was to examine the effects of central infusions ... -
Germ cell-specific proteins interact with the 3' untranslated regions of Prm-1 and Prm-2 mRNA
(Elsevier, 1994-12)The testis-specific mouse protamine genes (Prm-1 and Prm-2) are transcribed in haploid round spermatids, their mRNAs stored as cytoplasmic ribonucleoprotein particles and translated about 1 week later in ... -
MSY2 and MSY4 bind a conserved sequence in the 3' untranslated region of protamine 1 mRNA in vitro and in vivo
(American Society for Microbiology, 2001-10)Y-box proteins are major constituents of ribonucleoprotein particles (RNPs) which contain translationally silent mRNAs in gametic cells. We have recently shown that a sequence-specific RNA binding activity ... -
Regulation of galanin gene expression in gonadotropin-releasing hormone neurons during the estrous cycle of the rat
(Endocrine Society, 1993-04)Galanin is colocalized with GnRH in neurons of the hypothalamus and basal forebrain of female rats, and this neuropeptide may play a role in the generation of the midcycle surge of gonadotropin secretion. We ... -
Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat
(Endocrine Society, 1996-04)GH is thought to exert a short-loop feedback action on the hypothalamic somatostatin- and GH-releasing hormone (GHRH)-containing neurons. The direct actions of GH are mediated through GH receptors. In the ... -
Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
(Endocrine Society, 1997-11)The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which ... -
The role of galanin and its receptor in the feedback regulation of growth hormone secretion
(Endocrine Society, 1996-12)GH controls its own secretion through a mechanism involving short-loop feedback regulation of the synthesis and release of GH-releasing hormone (GHRH). GHRH neurons coexpress the peptide galanin, but the ... -
A sequence-specific RNA binding complex expressed in murine germ cells contains MSY2 and MSY4
(Elsevier, 2000-05)The protamine mRNAs are stored for up to 8 days as translationally repressed ribonucleoprotein particles during murine spermatogenesis. Translational repression of the protamine 1, Prm1, mRNA is controlled ... -
Serotonergic neurons are targets for leptin in the monkey
(Endocrine Society, 2001-01)Leptin is a secretory product of adipocytes that has been shown to affect food intake, metabolism, and reproduction. One site of leptin's action is the central nervous system, where the leptin receptor (Ob-R) ... -
Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development
(Endocrine Society, 1991-05)The secretory pattern of GH secretion is markedly sexually dimorphic in the adult rat. The patterning of GH secretion is determined by the coordinated activity of somatostatin (SS)- and GH-releasing hormone ... -
Testosterone regulates pro-opiomelanocortin gene expression in the primate brain
(Endocrine Society, 1991-04)Endogenous opioid peptides such as beta-endorphin, derived from proopiomelanocortin (POMC), have been widely implicated as serving an important role in the neuroendocrine regulation of the primate ...