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Galanin-like peptide as a possible link between metabolism and reproduction in the macaque

Show simple item record Scarlett, Jarrad M. en_US Smith, M. Susan en_US Grove, Kevin L. en_US Clifton, Donald K. en_US Cameron, Judy L. en_US Plant, Tony M. en_US Steiner, Robert A. en_US Cunningham, Matthew J. en_US Shahab, Muhammad en_US 2008-10-17T20:40:13Z 2008-10-17T20:40:13Z 2004-04 en_US
dc.identifier.citation J Clin Endocrinol Metab. 2004 Apr;89(4):1760-6 en_US
dc.description.abstract Galanin-like peptide (GALP) is a hypothalamic neuropeptide that has been implicated in the control of feeding, metabolism, and reproduction. The goal of this study was to examine the effects of central infusions of GALP on GnRH and LH secretion and to identify physiological factors that influence the expression of GALP mRNA in the brain of a primate species. Infusions of GALP into the lateral cerebroventricle of the macaque caused a significant increase in LH secretion, which was blocked by administration of the GnRH receptor antagonist acyline. However, the expression of GALP mRNA in the arcuate nucleus, as determined by in situ hybridization, was not regulated by either estradiol or progesterone. Compared with feeding ad libitum, fasting for 48 h produced a significant reduction in the hypothalamic expression of GALP mRNA. GALP neurons were found to express both neuropeptide Y Y1 receptor and serotonin 2C receptor by double-label in situ hybridization. Taken together, these results suggest that GALP neurons play a role of integrating metabolic signals, which are relayed to circuits controlling GnRH release in the macaque. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject reproduction en_US
dc.subject galanin-like peptide en_US
dc.subject in situ hybridization en_US
dc.subject metabolism en_US
dc.subject.mesh Injections, Intraventricular en_US
dc.subject.mesh Galanin-Like Peptide, administration & dosage, genetics, physiology en_US
dc.subject.mesh Macaca mulatta en_US
dc.subject.mesh Metabolism, physiology en_US
dc.subject.mesh Lateral Ventricles en_US
dc.subject.mesh Receptor, Serotonin, 5-HT2C, genetics en_US
dc.subject.mesh Neuropeptide Y, genetics en_US
dc.subject.mesh Progesterone, pharmacology en_US
dc.subject.mesh Reproduction, physiology en_US
dc.subject.mesh Male en_US
dc.subject.mesh Estradiol, pharmacology en_US
dc.subject.mesh Fasting en_US
dc.subject.mesh Animals en_US
dc.subject.mesh RNA, Messenger, metabolism en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Receptors, Neuropeptide Y, genetics en_US
dc.title Galanin-like peptide as a possible link between metabolism and reproduction in the macaque en_US
dc.type Article en_US

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