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dc.contributor.authorScarlett, Jarrad M.en_US
dc.contributor.authorSmith, M. Susanen_US
dc.contributor.authorGrove, Kevin L.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorCameron, Judy L.en_US
dc.contributor.authorPlant, Tony M.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorCunningham, Matthew J.en_US
dc.contributor.authorShahab, Muhammaden_US
dc.date.accessioned2008-10-17T20:40:13Z
dc.date.available2008-10-17T20:40:13Z
dc.date.issued2004-04en_US
dc.identifier.citationJ Clin Endocrinol Metab. 2004 Apr;89(4):1760-6en_US
dc.identifier.urihttp://hdl.handle.net/1773/4292
dc.description.abstractGalanin-like peptide (GALP) is a hypothalamic neuropeptide that has been implicated in the control of feeding, metabolism, and reproduction. The goal of this study was to examine the effects of central infusions of GALP on GnRH and LH secretion and to identify physiological factors that influence the expression of GALP mRNA in the brain of a primate species. Infusions of GALP into the lateral cerebroventricle of the macaque caused a significant increase in LH secretion, which was blocked by administration of the GnRH receptor antagonist acyline. However, the expression of GALP mRNA in the arcuate nucleus, as determined by in situ hybridization, was not regulated by either estradiol or progesterone. Compared with feeding ad libitum, fasting for 48 h produced a significant reduction in the hypothalamic expression of GALP mRNA. GALP neurons were found to express both neuropeptide Y Y1 receptor and serotonin 2C receptor by double-label in situ hybridization. Taken together, these results suggest that GALP neurons play a role of integrating metabolic signals, which are relayed to circuits controlling GnRH release in the macaque.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectreproductionen_US
dc.subjectgalanin-like peptideen_US
dc.subjectin situ hybridizationen_US
dc.subjectmetabolismen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshGalanin-Like Peptide, administration & dosage, genetics, physiologyen_US
dc.subject.meshMacaca mulattaen_US
dc.subject.meshMetabolism, physiologyen_US
dc.subject.meshLateral Ventriclesen_US
dc.subject.meshReceptor, Serotonin, 5-HT2C, geneticsen_US
dc.subject.meshNeuropeptide Y, geneticsen_US
dc.subject.meshProgesterone, pharmacologyen_US
dc.subject.meshReproduction, physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshEstradiol, pharmacologyen_US
dc.subject.meshFastingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshRNA, Messenger, metabolismen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshReceptors, Neuropeptide Y, geneticsen_US
dc.titleGalanin-like peptide as a possible link between metabolism and reproduction in the macaqueen_US
dc.typeArticleen_US


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