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dc.contributor.authorRivier, Jean E.en_US
dc.contributor.authorDahl, Kristine D.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorVale, Wylie W.en_US
dc.contributor.authorSoules, Michael R.en_US
dc.contributor.authorBremner, William J.en_US
dc.date.accessioned2008-10-17T20:40:18Z
dc.date.available2008-10-17T20:40:18Z
dc.date.issued1991-04en_US
dc.identifier.citationAm J Obstet Gynecol. 1991 Apr;164(4):989-94; discussion 994-6en_US
dc.identifier.urihttp://hdl.handle.net/1773/4297
dc.description.abstractWomen with luteal phase deficiency have been shown to have an increased frequency of luteinizing hormone pulses in the early follicular phase of the menstrual cycle. Because progesterone is known to modulate luteinizing hormone secretion, it has been hypothesized that the decreased progesterone secretion in a previous luteal phase deficiency cycle could lead to the abnormal luteinizing hormone secretory pattern in the ensuing early follicular phase. With the possibility that the higher luteinizing hormone pulse frequency might lead to another deficient luteal phase, it becomes conceivable that luteal phase deficiency could be self-perpetuating. To test this hypothesis, luteal phase deficiency was induced in six normal women by decreasing luteinizing hormone support of the corpus luteum with a gonadotropin-releasing hormone antagonist Nal-Glu, administered twice daily beginning in the midluteal phase after a control cycle. During the antagonist-treated luteal phase, each subject met the predetermined criteria for induced luteal phase deficiency: a 33% or greater decrease in integrated progesterone from the control cycle and an integrated progesterone level less than 100 ng/ml per day. Luteinizing hormone secretion patterns were determined by frequent blood sampling performed every 10 minutes for 12 hours in the early follicular phase of the control cycle and the cycle after antagonist administration. Daily luteal progesterone levels were measured in the control, treatment, and posttreatment cycles. Each volunteer served as her own control. Standard parameters were compared between the control and posttreatment pulse studies in the early follicular phase: (1) luteinizing hormone pulse frequency was 9.5 +/- 1.0 vs 10.0 +/- 0.9 pulses/12 hours, control vs posttreatment, respectively, p = 0.5; (2) luteinizing hormone pulse amplitude was 11.0 +/- 1.3 vs 12.0 +/- 2.2 ng/ml, p = 0.6; and (3) luteinizing hormone mean level was 19.4 +/- 2.3 vs 22.2 +/- 3.3 ng/ml, p = 0.1. Corpus luteum function was also compared between the control and posttreatment cycles. Luteal phase length was 13.7 +/- 0.6 vs 12.7 +/- 0.6 days, p = 0.08. Integrated progesterone values were 136.9 +/- 12.9 vs 130.5 +/- 11.3 ng/ml per day, p = 0.5. Therefore no discernible abnormalities in early follicular luteinizing hormone secretions or corpus luteum secretion of progesterone occurred after an induced luteal phase deficiency cycle.(ABSTRACT TRUNCATED AT 400 WORDS)en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectluteal phase deficiencyen_US
dc.subjectluteolysisen_US
dc.subjectprogesteroneen_US
dc.subjectgonadotropin-releasing hormone antagonisten_US
dc.subjectgonadotropin secretionen_US
dc.subjectcorpus luteumen_US
dc.subject.meshHumansen_US
dc.subject.meshGonadorelin, analogs & derivatives, antagonists & inhibitors, pharmacologyen_US
dc.subject.meshLuteinizing Hormone, secretionen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshLuteal Phaseen_US
dc.subject.meshAdulten_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshProgesterone, blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollicular Phaseen_US
dc.subject.meshCorpus Luteum, drug effects, physiologyen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.titleThe induction of premature luteolysis in normal women--follicular phase luteinizing hormone secretion and corpus luteum function in the subsequent cycleen_US
dc.typeArticleen_US


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