Show simple item record

dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorSmith, Jeremy T.en_US
dc.contributor.authorGottsch, Michelle L.en_US
dc.contributor.authorCrowley, W. F.en_US
dc.contributor.authorAcohido, B. V.en_US
dc.contributor.authorCunningham, Matthew J.en_US
dc.contributor.authorPopa, Simina M.en_US
dc.contributor.authorSeminara, S.en_US
dc.date.accessioned2008-10-17T20:40:30Z
dc.date.available2008-10-17T20:40:30Z
dc.date.issued2004-09en_US
dc.identifier.citationEndocrinology. 2004 Sep;145(9):4073-7. Epub 2004 Jun 24en_US
dc.identifier.urihttp://hdl.handle.net/1773/4310
dc.description.abstractKisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54. Mutations or targeted disruptions in the GPR54 gene cause hypogonadotropic hypogonadism in humans and mice, suggesting that kisspeptin signaling may be important for the regulation of gonadotropin secretion. To examine the effects of kisspeptin-54 (metastin) and kisspeptin-10 (the biologically active C-terminal decapeptide) on gonadotropin secretion in the mouse, we administered the kisspeptins directly into the lateral cerebral ventricle of the brain and demonstrated that both peptides stimulate LH secretion. Further characterization of kisspeptin-54 demonstrated that it stimulated both LH and FSH secretion, at doses as low as 1 fmol; moreover, this effect was shown to be blocked by pretreatment with acyline, a potent GnRH antagonist. To learn more about the functional anatomy of kisspeptins, we mapped the distribution of KiSS-1 mRNA in the hypothalamus. We observed that KiSS-1 mRNA is expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. We conclude that kisspeptin-GPR54 signaling may be part of the hypothalamic circuitry that governs the hypothalamic secretion of GnRH.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectmiceen_US
dc.subjectkisspeptinsen_US
dc.subjectgonadotropinen_US
dc.subjectsecretionen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHypothalamus, drug effects, metabolism, secretionen_US
dc.subject.meshProteins, genetics, metabolism, pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshLuteinizing Hormone, metabolism, secretionen_US
dc.subject.meshMaleen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshGonadorelin, metabolismen_US
dc.subject.meshRNA, Messenger, analysisen_US
dc.subject.meshReceptors, Neuropeptide, metabolismen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.titleA role for kisspeptins in the regulation of gonadotropin secretion in the mouseen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record