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dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorBaumgartner, James W.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorFraley, Gregory S.en_US
dc.contributor.authorShimada, Isseien_US
dc.date.accessioned2008-10-17T20:40:32Z
dc.date.available2008-10-17T20:40:32Z
dc.date.issued2003-04en_US
dc.identifier.citationEndocrinology. 2003 Apr;144(4):1143-6en_US
dc.identifier.urihttp://hdl.handle.net/1773/4312
dc.description.abstractGalanin and its newly discovered relative galanin-like peptide (GALP) are neuropeptides that are implicated in the neuroendocrine regulation of body weight and reproduction. GALP has been shown to bind in vitro to galanin receptor subtypes 1 and 2, but whether it has its own specific receptor(s) is unknown. We reasoned that if GALP acts through a receptor that is distinct from galanin receptors, then GALP should activate central pathways that are different from those activated by galanin. The purpose of this study was to determine whether galanin and GALP produce different patterns of neuronal activation within the hypothalamus. Quantitative analysis of Fos immunoreactivity showed that galanin induced a significantly greater number of Fos-positive nuclei in the paraventricular nucleus compared with GALP (P < 0.001); however, compared with galanin, GALP induced significantly more Fos-positive cells in the horizontal limb of the diagonal band of Broca, caudal preoptic area, arcuate nucleus, and median eminence (P < 0.05). These observations suggest that GALP and galanin act through different receptor-mediated pathways to exert their effects on the regulation of body weight and reproduction and identify target cells for GALP's specific actions in the hypothalamus, including the preoptic area, paraventricular and arcuate nuclei, and the median eminence.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectFos inductionen_US
dc.subjecthypothalamusen_US
dc.subjectgalanin-like peptideen_US
dc.subjectraten_US
dc.subjectgalaninen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshHypothalamus, drug effects, metabolismen_US
dc.subject.meshNerve Tissue Proteins, pharmacologyen_US
dc.subject.meshPreoptic Area, drug effects, metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshCerebrospinal Fluiden_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshProto-Oncogene Proteins c-fos, biosynthesisen_US
dc.subject.meshRatsen_US
dc.subject.meshParaventricular Hypothalamic Nucleus, drug effects, metabolismen_US
dc.subject.meshGalanin, pharmacologyen_US
dc.subject.meshGalanin-Like Peptideen_US
dc.subject.meshFeeding Behavior, drug effectsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArcuate Nucleus, drug effects, metabolismen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.titleDifferential patterns of Fos induction in the hypothalamus of the rat following central injections of galanin-like peptide and galaninen_US
dc.typeArticleen_US


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