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dc.contributor.authorMulders, Titia M. T.en_US
dc.contributor.authorMatsumoto, Alvin M.en_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorCoelingh-Bennink, Herjan J. T.en_US
dc.contributor.authorAnawalt, Bradley D.en_US
dc.contributor.authorHerbst, Karen L.en_US
dc.date.accessioned2008-10-17T20:41:00Z
dc.date.available2008-10-17T20:41:00Z
dc.date.issued2000-10en_US
dc.identifier.citationFertil Steril. 2000 Oct;74(4):707-14en_US
dc.identifier.urihttp://hdl.handle.net/1773/4331
dc.description.abstractOBJECTIVE: To test the hypothesis that oral desogestrel (DSG) plus testosterone would uniformly and rapidly suppress sperm concentrations in young men as effectively as levonorgestrel (LNG) plus testosterone and cause less high-density lipoprotein (HDL) suppression and weight gain. DESIGN: Single-blind, randomized trial. SETTING: VA Puget Sound and University of Washington, Seattle, Washington. PATIENT(S): Twenty-four healthy young men, aged 20-49. INTERVENTION(S): Subjects were randomized to three groups of men who were administered 6 months of therapy with oral DSG plus im testosterone enanthate: 150 microg of DSG plus 50 mg of testosterone (DSG 150-T 50), 150 microg of DSG plus 100 mg of testosterone (DSG 150-T 100) or 300 microg of DSG plus 100 mg of testosterone (DSG 300-T 100). We compared these three groups to two groups of historical controls of 100 mg of im testosterone alone or 150 microg of oral LNG plus 100 mg of im testosterone (LNG 125-T 100 group) enrolled in similar studies. MAIN OUTCOME MEASURE(S): Suppression of sperm counts to severe oligoazoospermia (sperm counts <1 x 10(6)/mL) and azoospermia, weight gain, and serum high-density cholesterol (HDL) suppression. RESULT(S): Azoospermia was achieved in all eight men receiving DSG 150-T 100 and seven of the eight men in the DSG 300-T 100 group. DSG 150 or 300 plus T 100 suppressed spermatogenesis as effectively as LNG 125-T 100 and more effectively than DSG 50-T 100 or testosterone alone. All groups tended to gain weight compared with their baseline, but the weight gain was greatest (and statistically significant) in the DSG 150-T 100, DSG 300-T 100, and LNG 125-T 100 groups. Serum HDL levels were modestly suppressed in all groups, and this effect was greatest in the DSG 300-T 100 and LNG 125-T 100 groups. CONCLUSION(S): The combination of DSG plus testosterone is a very effective regimen for suppression of spermatogenesis and has acceptably low side effects.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectmale contraceptionen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectandrologyen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectgonadotropinsen_US
dc.subjectcolchicineen_US
dc.subjectspermatogenesisen_US
dc.subjecttestosteroneen_US
dc.subjectklinefelter's syndromeen_US
dc.subject.meshSpermatogenesis, drug effectsen_US
dc.subject.meshBlood Chemical Analysisen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAdulten_US
dc.subject.meshContraceptive Agents, Male, pharmacologyen_US
dc.subject.meshContraceptives, Oral, Synthetic, pharmacologyen_US
dc.subject.meshCholesterol, blooden_US
dc.subject.meshSperm Counten_US
dc.subject.meshWeight Gain, drug effectsen_US
dc.subject.meshLevonorgestrel, pharmacologyen_US
dc.subject.meshDesogestrel, pharmacologyen_US
dc.subject.meshGynecomastia, chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshContraceptives, Oral, Hormonal, pharmacologyen_US
dc.subject.meshAcne Vulgaris, chemically induceden_US
dc.subject.meshHumansen_US
dc.subject.meshTestosterone, blood, pharmacologyen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshOligospermia, chemically induceden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshLipoproteins, HDL, blooden_US
dc.titleDesogestrel plus testosterone effectively suppresses spermatogenesis but also causes modest weight gain and high-density lipoprotein suppressionen_US
dc.typeArticleen_US


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