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Impairment of Spermatogonial Development and Spermiation after Testosterone-Induced Gonadotropin Suppression in Adult Monkeys (Macaca fascicularis)

Show simple item record Gu, Yi-Qun en_US Bremner, William J. en_US Balourdos, Georgia en_US McLachlan, Robert I. en_US Robertson, David M. en_US Wreford, Nigel G. en_US O'Donnell, Liza en_US Narula, Anita en_US 2008-10-17T20:41:10Z 2008-10-17T20:41:10Z 2001-04 en_US
dc.identifier.citation J Clin Endocrinol Metab. 2001 Apr;86(4):1814-22 en_US
dc.description.abstract Human male hormonal contraceptive regimens do not consistently induce azoospermia, and the basis of this variable response is unclear. This study used nine adult macaque monkeys (Macaca fascicularis) given testosterone (T) implants for 20 weeks to study changes in germ cell populations in relation to sperm output. Germ cell numbers were determined using the optical disector stereological method. Four animals achieved consistent azoospermia (azoo group), whereas five animals did not (nonazoo group). T-induced gonadotropin suppression in all animals decreased A pale (Ap) spermatogonia to 45% of baseline within 2 weeks, leading to decreased B spermatogonia (32--38%) and later germ cells (20--30%) after 14 and 20 weeks. Though the reduction in later germ cell types could be primarily attributed to the loss of spermatogonia, the data suggested that some cells were lost during the spermatocyte and spermatid phase of development. B spermatogonial number was more markedly suppressed in azoospermic animals, compared with the nonazoo group, as was the conversion ratio between Ap and B spermatogonia. Abnormal retention of elongated spermatids (failed spermiation) was also prominent in some animals after long-term T administration. We conclude that: 1) the variable suppression of sperm output is attributed to the degree of inhibition of germ cell development from type B spermatogonia onwards, and this is related to the degree of FSH suppression; and 2) inhibition of Ap and B spermatogonial development and of spermiation are the major defects caused by long-term T administration to monkeys. en_US
dc.language.iso en_US en_US
dc.publisher The Endocrine Society en_US
dc.subject male contraception en_US
dc.subject testosterone en_US
dc.subject andrology en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject gonadotropins en_US
dc.subject.mesh Luteinizing Hormone, blood en_US
dc.subject.mesh Gonadotropins, antagonists & inhibitors en_US
dc.subject.mesh Male en_US
dc.subject.mesh Sertoli Cells, physiology en_US
dc.subject.mesh Macaca fascicularis en_US
dc.subject.mesh Testosterone, pharmacokinetics, pharmacology en_US
dc.subject.mesh Sperm Count en_US
dc.subject.mesh Spermatogonia, classification, drug effects, physiology en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Follicle Stimulating Hormone, blood en_US
dc.subject.mesh Gonadal Steroid Hormones, pharmacokinetics, pharmacology en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Spermatozoa, cytology, drug effects, physiology en_US
dc.title Impairment of Spermatogonial Development and Spermiation after Testosterone-Induced Gonadotropin Suppression in Adult Monkeys (Macaca fascicularis) en_US
dc.type Article en_US

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