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dc.contributor.authorSchwall, Ralphen_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorMason, Anthony J.en_US
dc.contributor.authorSchmelzer, Charles H.en_US
dc.contributor.authorMcLachlan, Robert I.en_US
dc.contributor.authorDahl, Kristine D.en_US
dc.date.accessioned2008-10-17T20:41:16Z
dc.date.available2008-10-17T20:41:16Z
dc.date.issued1989-11en_US
dc.identifier.citationEndocrinology. 1989 Nov;125(5):2787-9en_US
dc.identifier.urihttp://hdl.handle.net/1773/4343
dc.description.abstractActivin-A is a homodimer of the beta A inhibin subunit that stimulates FSH secretion by pituitary cells in vitro; however, the physiological relevance of this effect is unknown. We have examined whether recombinant human activin-A (activin-A; 80 micrograms/kg/day iv infusion for 50.5 h) has in vivo bioactivity in the adult male macaque (n = 5). Serum FSH and LH bioactivity and serum testosterone (T) levels were measured on 2 control days and after 24 and 48 h of activin-A administration. Basal FSH levels increased significantly (p less than 0.05) by 17% at 24 h and 82% at 48 h during activin-A administration. No changes in basal LH or T levels were seen. The FSH and LH responses to GnRH (5 micrograms/kg, iv bolus) increased significantly (p less than 0.05) by 117% and 55% after 48 h of activin-A, respectively. A small (16%), but statistically significant (p less than 0.05), increase in the T response to the GnRH challenge was also noted. These data are preliminary evidence in support of a physiological role for activin-A in the control of gonadotropin secretion in the male primate.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectandrologyen_US
dc.subjectmale contraceptionen_US
dc.subjectklinefelter's syndromeen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectspermatogenesisen_US
dc.subjectcolchicineen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectgonadotropinsen_US
dc.subjecttestosteroneen_US
dc.subject.meshAnimalsen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshActivinsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGonadorelin, pharmacologyen_US
dc.subject.meshBiological Assayen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshLuteinizing Hormone, blood, pharmacology, secretionen_US
dc.subject.meshGranulosa Cells, drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshFollicle Stimulating Hormone, blood, pharmacology, secretionen_US
dc.subject.meshInhibins, pharmacologyen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshRecombinant Proteins, pharmacologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMacaca fascicularisen_US
dc.titleRecombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularisen_US
dc.typeArticleen_US


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