Recombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis

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Recombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis

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dc.contributor.author Schwall, Ralph en_US
dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Bremner, William J. en_US
dc.contributor.author Mason, Anthony J. en_US
dc.contributor.author Schmelzer, Charles H. en_US
dc.contributor.author McLachlan, Robert I. en_US
dc.contributor.author Dahl, Kristine D. en_US
dc.date.accessioned 2008-10-17T20:41:16Z
dc.date.available 2008-10-17T20:41:16Z
dc.date.issued 1989-11 en_US
dc.identifier.citation Endocrinology. 1989 Nov;125(5):2787-9 en_US
dc.identifier.uri http://hdl.handle.net/1773/4343
dc.description.abstract Activin-A is a homodimer of the beta A inhibin subunit that stimulates FSH secretion by pituitary cells in vitro; however, the physiological relevance of this effect is unknown. We have examined whether recombinant human activin-A (activin-A; 80 micrograms/kg/day iv infusion for 50.5 h) has in vivo bioactivity in the adult male macaque (n = 5). Serum FSH and LH bioactivity and serum testosterone (T) levels were measured on 2 control days and after 24 and 48 h of activin-A administration. Basal FSH levels increased significantly (p less than 0.05) by 17% at 24 h and 82% at 48 h during activin-A administration. No changes in basal LH or T levels were seen. The FSH and LH responses to GnRH (5 micrograms/kg, iv bolus) increased significantly (p less than 0.05) by 117% and 55% after 48 h of activin-A, respectively. A small (16%), but statistically significant (p less than 0.05), increase in the T response to the GnRH challenge was also noted. These data are preliminary evidence in support of a physiological role for activin-A in the control of gonadotropin secretion in the male primate. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject andrology en_US
dc.subject male contraception en_US
dc.subject klinefelter's syndrome en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject spermatogenesis en_US
dc.subject colchicine en_US
dc.subject reifenstein's syndrome en_US
dc.subject gonadotropins en_US
dc.subject testosterone en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Reference Values en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Activins en_US
dc.subject.mesh Female en_US
dc.subject.mesh Gonadorelin, pharmacology en_US
dc.subject.mesh Biological Assay en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Luteinizing Hormone, blood, pharmacology, secretion en_US
dc.subject.mesh Granulosa Cells, drug effects en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Male en_US
dc.subject.mesh Follicle Stimulating Hormone, blood, pharmacology, secretion en_US
dc.subject.mesh Inhibins, pharmacology en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Recombinant Proteins, pharmacology en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Macaca fascicularis en_US
dc.title Recombinant human activin-A stimulates basal FSH and GnRH-stimulated FSH and LH release in the adult male macaque, Macaca fascicularis en_US
dc.type Article en_US


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