Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain

ResearchWorks/Manakin Repository

Search ResearchWorks


Advanced Search

Browse

My Account

Statistics

Related Information

Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain

Show full item record

Title: Regulation of somatostatin and growth hormone-releasing hormone gene expression in the rat brain
Author: Argente, Jesus; Steiner, Robert A.; Chowen-Breed, Julie A.; Clifton, Donald K.; Tannenbaum, Gloria S.; Zeitler, Philip; Vician, Linda
Abstract: We have studied the regulation of somatostatin (SS) and growth hormone-releasing hormone (GHRH) gene expression in the brain of the laboratory rat. We report that hypophysectomy in the adult male reduces SS mRNA in cells of the periventricular nucleus (PeN), while GH reverses this effect. We demonstrate that cellular levels of SS mRNA in the PeN are higher in male compared to female animals. We report that castration reduces cellular levels of GHRH mRNA and SS mRNA in the arcuate nucleus and PeN, respectively, and that testosterone reverses this effect through an androgen receptor-dependent mechanism. Finally, we present a theoretical model to explain the generation of the ultradian rhythm in GH secretion, which implicates the reciprocal interaction between GH feedback and the transcriptional regulation of the SS and GHRH genes and the kinetics of these relationships.
URI: http://hdl.handle.net/1773/4346

Files in this item

Files Size Format View
Metab_1990_Regulation_Somatostatin_Growth.pdf 100.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record