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dc.contributor.authorWeinshenker, Daviden_US
dc.contributor.authorHohmann, John G.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorGottsch, Michelle L.en_US
dc.contributor.authorZeng, Hongkuien_US
dc.date.accessioned2008-10-17T20:41:26Z
dc.date.available2008-10-17T20:41:26Z
dc.date.issued2005-06en_US
dc.identifier.citationMol Cell Biol. 2005 Jun;25(11):4804-11en_US
dc.identifier.urihttp://hdl.handle.net/1773/4354
dc.description.abstractGalanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and GALR3), which bind to galanin with different affinities and have their own unique distributions, signaling mechanisms, and putative functions in the brain and peripheral nervous system. To gain further insight into the possible physiological significance of GALR2, we created mutant mice that were deficient in GALR2 and compared their phenotype to that of wild-type (WT) littermate or age-matched controls, with respect to basic motor and sensory function, feeding behavior, reproduction, mood, learning and memory, and seizure susceptibility. Phenotypic analysis revealed that animals bearing a deletion of GALR2 did not differ significantly from their WT controls in any of the measured variables. We conclude that either GALR2 plays no role in these physiological functions or through redundancy or compensation these mutant animals can adapt to the congenital absence of GALR2. It is also conceivable that GALR2 plays only a subtle role in some of these functions and that the impact of its loss could not be detected by the analytical procedures used here.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society for Microbiologyen_US
dc.subjectphenotypic analysisen_US
dc.subjectgalaninen_US
dc.subjectmiceen_US
dc.subjectGALR2en_US
dc.subject.meshMemoryen_US
dc.subject.meshMaleen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshReceptor, Galanin, Type 2, deficiency, genetics, physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshFeeding Behavioren_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshReproduction, geneticsen_US
dc.subject.meshResearch Support, N.I.H., Extramuralen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshLearningen_US
dc.subject.meshFemaleen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weight, geneticsen_US
dc.subject.meshSeizures, geneticsen_US
dc.titlePhenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)en_US
dc.typeArticleen_US


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