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Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2)

Show simple item record Weinshenker, David en_US Hohmann, John G. en_US Steiner, Robert A. en_US Clifton, Donald K. en_US Gottsch, Michelle L. en_US Zeng, Hongkui en_US 2008-10-17T20:41:26Z 2008-10-17T20:41:26Z 2005-06 en_US
dc.identifier.citation Mol Cell Biol. 2005 Jun;25(11):4804-11 en_US
dc.description.abstract Galanin is a neuropeptide implicated in the regulation of feeding, reproduction, cognition, nociception, and seizure susceptibility. There are three known galanin receptor (GALR) subtypes (GALR1, GALR2, and GALR3), which bind to galanin with different affinities and have their own unique distributions, signaling mechanisms, and putative functions in the brain and peripheral nervous system. To gain further insight into the possible physiological significance of GALR2, we created mutant mice that were deficient in GALR2 and compared their phenotype to that of wild-type (WT) littermate or age-matched controls, with respect to basic motor and sensory function, feeding behavior, reproduction, mood, learning and memory, and seizure susceptibility. Phenotypic analysis revealed that animals bearing a deletion of GALR2 did not differ significantly from their WT controls in any of the measured variables. We conclude that either GALR2 plays no role in these physiological functions or through redundancy or compensation these mutant animals can adapt to the congenital absence of GALR2. It is also conceivable that GALR2 plays only a subtle role in some of these functions and that the impact of its loss could not be detected by the analytical procedures used here. en_US
dc.language.iso en_US en_US
dc.publisher American Society for Microbiology en_US
dc.subject phenotypic analysis en_US
dc.subject galanin en_US
dc.subject mice en_US
dc.subject GALR2 en_US
dc.subject.mesh Memory en_US
dc.subject.mesh Male en_US
dc.subject.mesh Mice, Knockout en_US
dc.subject.mesh Receptor, Galanin, Type 2, deficiency, genetics, physiology en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Feeding Behavior en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Reproduction, genetics en_US
dc.subject.mesh Research Support, N.I.H., Extramural en_US
dc.subject.mesh Sex Factors en_US
dc.subject.mesh Phenotype en_US
dc.subject.mesh Gene Deletion en_US
dc.subject.mesh Learning en_US
dc.subject.mesh Female en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Body Weight, genetics en_US
dc.subject.mesh Seizures, genetics en_US
dc.title Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2) en_US
dc.type Article en_US

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