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dc.contributor.authorBremner, William J.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorSoules, Michael R.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.date.accessioned2008-10-17T20:41:34Z
dc.date.available2008-10-17T20:41:34Z
dc.date.issued1984-05en_US
dc.identifier.citationObstet Gynecol. 1984 May;63(5):626-9en_US
dc.identifier.urihttp://hdl.handle.net/1773/4363
dc.description.abstractLuteal phase deficiency is usually a problem of inadequate progesterone production associated with inadequate ovarian follicular development. The hypothesis that luteal phase deficiency results from an abnormal secretion pattern of luteinizing hormone (LH) was tested in these women. To this end, the early follicular LH secretion pattern in four women with luteal phase deficiency was characterized and compared with patterns in normal women. Blood samples were obtained through indwelling catheters every ten minutes for eight hours (10 AM to 6 PM), and plasma levels of LH and FSH were measured. Luteinizing hormone and FSH secretion profiles were analyzed for pulse frequency, amplitude, and mean plasma level. A significantly greater LH pulse frequency in women with luteal phase deficiency was observed when compared with the frequency in normal controls (luteal phase deficiency, 10.5 pulses/eight hours; normal, 5.2 pulses/eight hours; P less than or equal to .05). The mean FSH concentration was less in the women with luteal phase deficiency, but the level was not significant. These data suggest that the abnormal LH secretion pattern observed in women with luteal phase deficiency is responsible for their inadequate luteal phase progesterone secretion and their infertility.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectmale contraceptionen_US
dc.subjectandrologyen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjecttestosteroneen_US
dc.subjectgonadotropinsen_US
dc.subjectcolchicineen_US
dc.subjectklinefelter's syndromeen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectspermatogenesisen_US
dc.subject.meshFollicle Stimulating Hormone, secretionen_US
dc.subject.meshFemaleen_US
dc.subject.meshInfertility, Female, physiopathologyen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshHumansen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshLuteinizing Hormone, deficiency, secretionen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCorpus Luteum, physiopathologyen_US
dc.subject.meshAdulten_US
dc.titleAbnormal patterns of pulsatile luteinizing hormone in women with luteal phase deficiencyen_US
dc.typeArticleen_US


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