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Luteal phase deficiency: characterization of reproductive hormones over the menstrual cycle

Show simple item record Dahl, Kristine D. en_US Ek, Marit en_US Bremner, William J. en_US Cohen, Nancy L. en_US Soules, Michael R. en_US McLachlan, Robert I. en_US 2008-10-17T20:41:42Z 2008-10-17T20:41:42Z 1989-10 en_US
dc.identifier.citation J Clin Endocrinol Metab. 1989 Oct;69(4):804-12 en_US
dc.description.abstract The recurrent deficiency of progesterone (P) secretion by the corpus luteum has been associated with infertility and habitual abortion and given the clinical diagnosis of luteal phase deficiency (LPD). There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. In this study we have examined reproductive hormone levels and preovulatory follicular size in women with LPD (n = 10). For the purposes of this study, LPD was determined by an endometrial biopsy in the studied cycle that was more than 2 days out of phase. These biopsies were performed in women with infertility or habitual abortion who exhibited an out of phase biopsy in a prior cycle. The control group consisted of 28 normal women. Daily serum levels of the following hormones were determined in each subject: LH and FSH [immuno- and bioactive (LH-immuno and LH-bio)], P, estradiol (E2), and inhibin. The LPD women exhibited significant decreases in integrated luteal phase levels of inhibin [10,615 +/- 898 vs. 13,560 +/- 662 (U/L).days; P less than 0.02] and E2 [5,015 +/- 275 vs. 6,435 +/- 393 (pmol/L).days (1366 vs. 1753 (pg/mL).days); P less than 0.05] in addition to the expected decrease in P [280 +/- 23 vs. 420 +/- 23 (nmol/L).days (88 vs. 132 (ng/mL).days); P less than 0.01]. On days 6-11 after the LH surge (day 0), there was a significant (P less than 0.05) decrease in mean LH-bio levels in LPD compared with those in normal women (146 +/- 26 vs. 212 +/- 24 micrograms/L). The midcycle LH surge was deficient in LPD when both LH-immuno [482 +/- 30 vs. 672 +/- 43 (micrograms/L).days; P less than 0.01] and LH-bio [1711 +/- 179 vs. 2248 +/- 226 (micrograms/L).days; P less than 0.05] levels were compared with normal values. When comparing the follicular phase in LPD with that in normal women, similar follicle size, peak and integrated E2 levels, and mean LH and FSH (immuno and bio) levels were found. The only follicular phase abnormality noted in this study was decreased mean levels of serum inhibin in the early and midfollicular phases (221 +/- 19 vs. 308 +/- 25 U/L; P less than 0.01). In this group of women with LPD, low levels of inhibin in the follicular phase were consistent with the concept of a defect in function of the preovulatory follicle, possibly as a result of previously described defects in gonadotropin secretion in this condition.(ABSTRACT TRUNCATED AT 400 WORDS) en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject male contraception en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject andrology en_US
dc.subject reifenstein's syndrome en_US
dc.subject gonadotropins en_US
dc.subject colchicine en_US
dc.subject spermatogenesis en_US
dc.subject testosterone en_US
dc.subject klinefelter's syndrome en_US
dc.subject.mesh Corpus Luteum, physiopathology en_US
dc.subject.mesh Reference Values en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Estradiol, blood en_US
dc.subject.mesh Galactorrhea, physiopathology en_US
dc.subject.mesh Endometrium, pathology en_US
dc.subject.mesh Luteinizing Hormone, blood en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Infertility, Female, blood, physiopathology en_US
dc.subject.mesh Pregnancy en_US
dc.subject.mesh Follicle Stimulating Hormone, blood en_US
dc.subject.mesh Abortion, Habitual, blood, physiopathology en_US
dc.subject.mesh Inhibins, blood en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Prolactin, blood en_US
dc.subject.mesh Progesterone, blood en_US
dc.subject.mesh Menstrual Cycle en_US
dc.title Luteal phase deficiency: characterization of reproductive hormones over the menstrual cycle en_US
dc.type Article en_US

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