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dc.contributor.authorDahl, Kristine D.en_US
dc.contributor.authorEk, Mariten_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorCohen, Nancy L.en_US
dc.contributor.authorSoules, Michael R.en_US
dc.contributor.authorMcLachlan, Robert I.en_US
dc.date.accessioned2008-10-17T20:41:42Z
dc.date.available2008-10-17T20:41:42Z
dc.date.issued1989-10en_US
dc.identifier.citationJ Clin Endocrinol Metab. 1989 Oct;69(4):804-12en_US
dc.identifier.urihttp://hdl.handle.net/1773/4370
dc.description.abstractThe recurrent deficiency of progesterone (P) secretion by the corpus luteum has been associated with infertility and habitual abortion and given the clinical diagnosis of luteal phase deficiency (LPD). There is evidence that both follicular and luteal phase abnormalities can result in LPD cycles. In this study we have examined reproductive hormone levels and preovulatory follicular size in women with LPD (n = 10). For the purposes of this study, LPD was determined by an endometrial biopsy in the studied cycle that was more than 2 days out of phase. These biopsies were performed in women with infertility or habitual abortion who exhibited an out of phase biopsy in a prior cycle. The control group consisted of 28 normal women. Daily serum levels of the following hormones were determined in each subject: LH and FSH [immuno- and bioactive (LH-immuno and LH-bio)], P, estradiol (E2), and inhibin. The LPD women exhibited significant decreases in integrated luteal phase levels of inhibin [10,615 +/- 898 vs. 13,560 +/- 662 (U/L).days; P less than 0.02] and E2 [5,015 +/- 275 vs. 6,435 +/- 393 (pmol/L).days (1366 vs. 1753 (pg/mL).days); P less than 0.05] in addition to the expected decrease in P [280 +/- 23 vs. 420 +/- 23 (nmol/L).days (88 vs. 132 (ng/mL).days); P less than 0.01]. On days 6-11 after the LH surge (day 0), there was a significant (P less than 0.05) decrease in mean LH-bio levels in LPD compared with those in normal women (146 +/- 26 vs. 212 +/- 24 micrograms/L). The midcycle LH surge was deficient in LPD when both LH-immuno [482 +/- 30 vs. 672 +/- 43 (micrograms/L).days; P less than 0.01] and LH-bio [1711 +/- 179 vs. 2248 +/- 226 (micrograms/L).days; P less than 0.05] levels were compared with normal values. When comparing the follicular phase in LPD with that in normal women, similar follicle size, peak and integrated E2 levels, and mean LH and FSH (immuno and bio) levels were found. The only follicular phase abnormality noted in this study was decreased mean levels of serum inhibin in the early and midfollicular phases (221 +/- 19 vs. 308 +/- 25 U/L; P less than 0.01). In this group of women with LPD, low levels of inhibin in the follicular phase were consistent with the concept of a defect in function of the preovulatory follicle, possibly as a result of previously described defects in gonadotropin secretion in this condition.(ABSTRACT TRUNCATED AT 400 WORDS)en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectmale contraceptionen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectandrologyen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectgonadotropinsen_US
dc.subjectcolchicineen_US
dc.subjectspermatogenesisen_US
dc.subjecttestosteroneen_US
dc.subjectklinefelter's syndromeen_US
dc.subject.meshCorpus Luteum, physiopathologyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshAdulten_US
dc.subject.meshEstradiol, blooden_US
dc.subject.meshGalactorrhea, physiopathologyen_US
dc.subject.meshEndometrium, pathologyen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfertility, Female, blood, physiopathologyen_US
dc.subject.meshPregnancyen_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshAbortion, Habitual, blood, physiopathologyen_US
dc.subject.meshInhibins, blooden_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshProlactin, blooden_US
dc.subject.meshProgesterone, blooden_US
dc.subject.meshMenstrual Cycleen_US
dc.titleLuteal phase deficiency: characterization of reproductive hormones over the menstrual cycleen_US
dc.typeArticleen_US


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