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dc.contributor.authorStanton, Peter G.en_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorO'Donnell, Lizaen_US
dc.contributor.authorMcLachlan, Robert I.en_US
dc.contributor.authorRobertson, David M.en_US
dc.contributor.authorNarula, Anitaen_US
dc.contributor.authorGu, Yi-Qunen_US
dc.date.accessioned2008-10-17T20:41:58Z
dc.date.available2008-10-17T20:41:58Z
dc.date.issued2002-07en_US
dc.identifier.citationJ Clin Endocrinol Metab. 2002 Jul;87(7):3399-406en_US
dc.identifier.urihttp://hdl.handle.net/1773/4388
dc.description.abstractSex steroid-based male contraceptive regimens do not induce consistent azoospermia. The reason for this variable response is obscure. We used normal adult male monkeys, Macaca fascicularis (n = 9) as a model of testosterone (T)-induced gonadotropin suppression to understand the basis for variability in spermatogenic suppression during hormonal contraception. As observed in men, T administration to these monkeys induced azoospermia in some animals and variable degrees of spermatogenic suppression in others. Based on their sperm counts, we divided these animals into two groups: azoospermic (azoo; n = 4) and nonazoospermic (nonazoo; n = 5) groups. Sperm density, testis volumes, and serum T, bioassayable LH (bioLH), immunoassayable FSH (immunoFSH), bioassayable FSH (bioFSH), and inhibin B were examined every 2 wk during the control period, 20 wk of T administration using SILASTIC brand (Dow Corning Corp.) implants, and recovery. Testes were biopsied for estimation of intratesticular T, dihydrotestosterone, and 5alpha-androstane-3alpha,17beta-diol. Serum T levels increased 1.5- to 2-fold, leading to decreased bioLH levels (48% of control) and intratesticular T levels (15% of control); neither LH nor intratesticular T levels differed between the azoo and nonazoo groups. In contrast, serum levels of FSH, by both bio- and immunoassay, during T administration were significantly lower in the azoo than in the nonazoo group. These results suggest that the degree of suppression of spermatogenesis is closely related to the degree of suppression of FSH levels and not to the levels of intratesticular androgens or to serum LH. These results imply that FSH plays a key role in supporting spermatogenesis in monkeys in this experimental regimen and suggest that maximal suppression of FSH may be essential to ensure consistent azoospermia in men during hormonal contraceptionen_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectandrologyen_US
dc.subjectmale contraceptionen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectgonadotropinsen_US
dc.subjecttestosteroneen_US
dc.subject.meshInhibins, blooden_US
dc.subject.meshGonadal Steroid Hormones, metabolism, pharmacologyen_US
dc.subject.meshMacaca fascicularisen_US
dc.subject.meshOligospermia, chemically induced, physiopathologyen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshAndrogens, metabolismen_US
dc.subject.meshSpermatogenesis, drug effectsen_US
dc.subject.meshOrgan Size, drug effectsen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshTestosterone, blood, metabolism, pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshBody Weighten_US
dc.subject.meshFollicle Stimulating Hormone, antagonists & inhibitors, blooden_US
dc.subject.meshAnimalsen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshTestis, anatomy & histologyen_US
dc.titleVariability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgensen_US
dc.typeArticleen_US


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