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Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens

Show simple item record Stanton, Peter G. en_US Bremner, William J. en_US O'Donnell, Liza en_US McLachlan, Robert I. en_US Robertson, David M. en_US Narula, Anita en_US Gu, Yi-Qun en_US 2008-10-17T20:41:58Z 2008-10-17T20:41:58Z 2002-07 en_US
dc.identifier.citation J Clin Endocrinol Metab. 2002 Jul;87(7):3399-406 en_US
dc.description.abstract Sex steroid-based male contraceptive regimens do not induce consistent azoospermia. The reason for this variable response is obscure. We used normal adult male monkeys, Macaca fascicularis (n = 9) as a model of testosterone (T)-induced gonadotropin suppression to understand the basis for variability in spermatogenic suppression during hormonal contraception. As observed in men, T administration to these monkeys induced azoospermia in some animals and variable degrees of spermatogenic suppression in others. Based on their sperm counts, we divided these animals into two groups: azoospermic (azoo; n = 4) and nonazoospermic (nonazoo; n = 5) groups. Sperm density, testis volumes, and serum T, bioassayable LH (bioLH), immunoassayable FSH (immunoFSH), bioassayable FSH (bioFSH), and inhibin B were examined every 2 wk during the control period, 20 wk of T administration using SILASTIC brand (Dow Corning Corp.) implants, and recovery. Testes were biopsied for estimation of intratesticular T, dihydrotestosterone, and 5alpha-androstane-3alpha,17beta-diol. Serum T levels increased 1.5- to 2-fold, leading to decreased bioLH levels (48% of control) and intratesticular T levels (15% of control); neither LH nor intratesticular T levels differed between the azoo and nonazoo groups. In contrast, serum levels of FSH, by both bio- and immunoassay, during T administration were significantly lower in the azoo than in the nonazoo group. These results suggest that the degree of suppression of spermatogenesis is closely related to the degree of suppression of FSH levels and not to the levels of intratesticular androgens or to serum LH. These results imply that FSH plays a key role in supporting spermatogenesis in monkeys in this experimental regimen and suggest that maximal suppression of FSH may be essential to ensure consistent azoospermia in men during hormonal contraception en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject andrology en_US
dc.subject male contraception en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject gonadotropins en_US
dc.subject testosterone en_US
dc.subject.mesh Inhibins, blood en_US
dc.subject.mesh Gonadal Steroid Hormones, metabolism, pharmacology en_US
dc.subject.mesh Macaca fascicularis en_US
dc.subject.mesh Oligospermia, chemically induced, physiopathology en_US
dc.subject.mesh Luteinizing Hormone, blood en_US
dc.subject.mesh Androgens, metabolism en_US
dc.subject.mesh Spermatogenesis, drug effects en_US
dc.subject.mesh Organ Size, drug effects en_US
dc.subject.mesh Reference Values en_US
dc.subject.mesh Testosterone, blood, metabolism, pharmacology en_US
dc.subject.mesh Male en_US
dc.subject.mesh Body Weight en_US
dc.subject.mesh Follicle Stimulating Hormone, antagonists & inhibitors, blood en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Testis, anatomy & histology en_US
dc.title Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens en_US
dc.type Article en_US

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