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dc.contributor.authorValdiserri, Alessandroen_US
dc.contributor.authorPavani, Annaen_US
dc.contributor.authorPaulsen, C. Alvinen_US
dc.contributor.authorCapelli, Maurizioen_US
dc.contributor.authorMotta, Robertoen_US
dc.contributor.authorIncorvaia, Loredanaen_US
dc.contributor.authorFlamigni, Carloen_US
dc.contributor.authorMeriggiola, M. Cristinaen_US
dc.contributor.authorBremner, William J.en_US
dc.date.accessioned2008-10-17T20:42:01Z
dc.date.available2008-10-17T20:42:01Z
dc.date.issued1996-08en_US
dc.identifier.citationJ Clin Endocrinol Metab. 1996 Aug;81(8):3018-23en_US
dc.identifier.urihttp://hdl.handle.net/1773/4391
dc.description.abstractIn this study we tested the effectiveness of the combined administration of cyproterone acetate (CPA) and testosterone enanthate (TE) in suppressing spermatogenesis. After a control phase of 3 months, 15 normal men were randomized to receive TE (100 mg/week) plus CPA at a dose of 100 mg/day (CPA-100; n = 5) or 50 mg/day (CPA-50; n = 5) or TE (100 mg/week) alone (n = 5) for 16 weeks. Semen analysis was performed every 2 weeks. Every 4 weeks, fasting blood samples were drawn for the measurement of LH, FSH, testosterone, estradiol, and biochemical and hematological parameters; subjects underwent a physical examination; and they and their partners filled in a sexual and behavioral questionnaire. Regardless of the dose, each of the 10 subjects receiving CPA plus TE became azoospermic, whereas only 3 of 5 subjects treated with TE alone achieved azoospermia. Times to azoospermia were 6.8 +/- 0.5, 8.4 +/- 1.0, and 14.0 +/- 1.2 weeks in groups CPA-100, CPA-50, and TE alone, respectively (P = NS). Throughout treatment, both gonadotropins tended to be higher in the TE alone group than in the other groups. This difference was mostly due to the higher gonadotropin levels present in the 2 men treated with TE alone that remained oligospermic. No difference in testosterone or estradiol levels was found among the groups. No significant change in lipoprotein levels or liver function tests could be detected. In the CPA-100 and CPA-50 groups, hemoglobin, hematocrit, and red blood cells were lower at the end of the treatment phase, whereas no change was detected in TE alone group. A tendency for a decrease in body weight was detected in subjects treated with CPA, whereas there was no change in subjects receiving TE alone. At the end of the treatment phase, a decrease in testis size was present in all groups. There was no significant change in sexual function, aggressive behavior, mood states, or satisfaction with relationship in any group. These results suggest that the combined administration of CPA and TE is very effective in suppressing spermatogenesis and may represent a promising regimen for reversible contraception in males.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectcolchicineen_US
dc.subjectspermatogenesisen_US
dc.subjectgonadotropinsen_US
dc.subjectmale contraceptionen_US
dc.subjectklinefelter's syndromeen_US
dc.subjectreifenstein's syndromeen_US
dc.subjecttestosteroneen_US
dc.subjectandrologyen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subject.meshSemen, drug effectsen_US
dc.subject.meshSexual Behavioren_US
dc.subject.meshContraceptive Agents, Male, pharmacologyen_US
dc.subject.meshDrug Synergismen_US
dc.subject.meshAdulten_US
dc.subject.meshTestosterone, analogs & derivatives, pharmacologyen_US
dc.subject.meshLipids, blooden_US
dc.subject.meshElectrolytes, blooden_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshMaleen_US
dc.subject.meshCyproterone Acetate, pharmacologyen_US
dc.subject.meshHumansen_US
dc.subject.meshTestis, anatomy & histology, drug effectsen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshOrgan Size, drug effectsen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.titleA combined regimen of cyproterone acetate and testosterone enanthate as a potentially highly effective male contraceptiveen_US
dc.typeArticleen_US


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