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dc.contributor.authorHoldcraft, Robert W.en_US
dc.contributor.authorBraun, Robert E.en_US
dc.date.accessioned2008-10-17T20:42:07Z
dc.date.available2008-10-17T20:42:07Z
dc.date.issued2004-01en_US
dc.identifier.citationDevelopment. 2004 Jan;131(2):459-67en_US
dc.identifier.urihttp://hdl.handle.net/1773/4398
dc.description.abstractAndrogen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement is thought to be mediated by Sertoli cells and its genetic and pharmacological disruption is manifested in spermatocytes as meiotic arrest. Through studies of a hypomorphic and conditional allele of the androgen receptor (Ar) gene, we have uncovered a dual post-meiotic requirement for androgen receptor activity during male germ cell differentiation. Observations in Ar hypomorphic animals demonstrate that terminal differentiation of spermatids and their release from the seminiferous epithelium is AR dependent and maximally sensitive to AR depletion within the testis. Cell-specific disruption of Ar in Sertoli cells of hypomorphic animals further shows that progression of late-round spermatids to elongating steps is sensitive to loss of Sertoli cell AR function, but that progression through meiosis and early-round spermatid differentiation are surprisingly unaffected.en_US
dc.language.isoen_USen_US
dc.publisherCompany Of Biologists Limiteden_US
dc.subjectspermatogenesisen_US
dc.subjectmouseen_US
dc.subjectSertolien_US
dc.subjectandrogen receptoren_US
dc.subject.meshPhenotypeen_US
dc.subject.meshMutationen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshSpermatids, cytology, metabolismen_US
dc.subject.meshReceptors, Androgen, deficiency, genetics, physiologyen_US
dc.subject.meshAllelesen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshMiceen_US
dc.subject.meshSpermatogenesis, genetics, physiologyen_US
dc.subject.meshTestis, abnormalitiesen_US
dc.subject.meshEpididymis, abnormalitiesen_US
dc.subject.meshSertoli Cells, metabolismen_US
dc.subject.meshMice, Mutant Strainsen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshHaploidyen_US
dc.subject.meshMaleen_US
dc.titleAndrogen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatidsen_US
dc.typeArticleen_US


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