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Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids

Show simple item record Holdcraft, Robert W. en_US Braun, Robert E. en_US 2008-10-17T20:42:07Z 2008-10-17T20:42:07Z 2004-01 en_US
dc.identifier.citation Development. 2004 Jan;131(2):459-67 en_US
dc.description.abstract Androgen receptor function is required for male embryonic sexual differentiation, pubertal development and the regulation of spermatogenesis in mammals. During spermatogenesis, this requirement is thought to be mediated by Sertoli cells and its genetic and pharmacological disruption is manifested in spermatocytes as meiotic arrest. Through studies of a hypomorphic and conditional allele of the androgen receptor (Ar) gene, we have uncovered a dual post-meiotic requirement for androgen receptor activity during male germ cell differentiation. Observations in Ar hypomorphic animals demonstrate that terminal differentiation of spermatids and their release from the seminiferous epithelium is AR dependent and maximally sensitive to AR depletion within the testis. Cell-specific disruption of Ar in Sertoli cells of hypomorphic animals further shows that progression of late-round spermatids to elongating steps is sensitive to loss of Sertoli cell AR function, but that progression through meiosis and early-round spermatid differentiation are surprisingly unaffected. en_US
dc.language.iso en_US en_US
dc.publisher Company Of Biologists Limited en_US
dc.subject spermatogenesis en_US
dc.subject mouse en_US
dc.subject Sertoli en_US
dc.subject androgen receptor en_US
dc.subject.mesh Phenotype en_US
dc.subject.mesh Mutation en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Spermatids, cytology, metabolism en_US
dc.subject.mesh Receptors, Androgen, deficiency, genetics, physiology en_US
dc.subject.mesh Alleles en_US
dc.subject.mesh Cell Differentiation en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Spermatogenesis, genetics, physiology en_US
dc.subject.mesh Testis, abnormalities en_US
dc.subject.mesh Epididymis, abnormalities en_US
dc.subject.mesh Sertoli Cells, metabolism en_US
dc.subject.mesh Mice, Mutant Strains en_US
dc.subject.mesh Mice, Transgenic en_US
dc.subject.mesh Mice, Inbred C57BL en_US
dc.subject.mesh Haploidy en_US
dc.subject.mesh Male en_US
dc.title Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids en_US
dc.type Article en_US

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