Inhibition of fetal growth and survival by testosterone administration to pregnant sheep

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Inhibition of fetal growth and survival by testosterone administration to pregnant sheep

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dc.contributor.author Bremner, William J. en_US
dc.contributor.author Cumming, I. A. en_US
dc.date.accessioned 2008-10-17T20:42:11Z
dc.date.available 2008-10-17T20:42:11Z
dc.date.issued 1978-03 en_US
dc.identifier.citation Metabolism. 1978 Mar;27(3):253-5 en_US
dc.identifier.uri http://hdl.handle.net/1773/4403
dc.description.abstract Testosterone (as testosterone enanthate, 250 mg i.m. every 2 wk) was administered to pregnant ewes (n = 16), and injections of vehicle were used in 10 control pregnant ewes between days 75 of gestation and term (day 147). Fetal survival (7 of 16 in the treated group versus 10 of 10 in the controls) and growth (birth weights 4.00 +- 0.51 kg in the treated group versus 5.79 +- 0.93, mean +- SD, in the controls) were markedly impaired by testosterone administration. The mechanism of the testosterone effect is unknown, but could be through metabolism to estrogens by the feto-placental unit. These results imply that alterations in the production or metabolism of androgens by the mother or the feto-placement unit may exert important effects on fetal growth and survival. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject gonadotropins en_US
dc.subject testosterone en_US
dc.subject reifenstein's syndrome en_US
dc.subject klinefelter's syndrome en_US
dc.subject spermatogenesis en_US
dc.subject andrology en_US
dc.subject male contraception en_US
dc.subject colchicine en_US
dc.subject.mesh Pregnancy en_US
dc.subject.mesh Male en_US
dc.subject.mesh Testosterone, pharmacology en_US
dc.subject.mesh Sheep en_US
dc.subject.mesh Birth Weight, drug effects en_US
dc.subject.mesh Fetal Death, chemically induced en_US
dc.subject.mesh Fetus, drug effects, physiology en_US
dc.subject.mesh Female en_US
dc.subject.mesh Animals en_US
dc.title Inhibition of fetal growth and survival by testosterone administration to pregnant sheep en_US
dc.type Article en_US


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