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dc.contributor.authorBremner, William J.en_US
dc.contributor.authorCumming, I. A.en_US
dc.date.accessioned2008-10-17T20:42:11Z
dc.date.available2008-10-17T20:42:11Z
dc.date.issued1978-03en_US
dc.identifier.citationMetabolism. 1978 Mar;27(3):253-5en_US
dc.identifier.urihttp://hdl.handle.net/1773/4403
dc.description.abstractTestosterone (as testosterone enanthate, 250 mg i.m. every 2 wk) was administered to pregnant ewes (n = 16), and injections of vehicle were used in 10 control pregnant ewes between days 75 of gestation and term (day 147). Fetal survival (7 of 16 in the treated group versus 10 of 10 in the controls) and growth (birth weights 4.00 +- 0.51 kg in the treated group versus 5.79 +- 0.93, mean +- SD, in the controls) were markedly impaired by testosterone administration. The mechanism of the testosterone effect is unknown, but could be through metabolism to estrogens by the feto-placental unit. These results imply that alterations in the production or metabolism of androgens by the mother or the feto-placement unit may exert important effects on fetal growth and survival.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectgonadotropinsen_US
dc.subjecttestosteroneen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectklinefelter's syndromeen_US
dc.subjectspermatogenesisen_US
dc.subjectandrologyen_US
dc.subjectmale contraceptionen_US
dc.subjectcolchicineen_US
dc.subject.meshPregnancyen_US
dc.subject.meshMaleen_US
dc.subject.meshTestosterone, pharmacologyen_US
dc.subject.meshSheepen_US
dc.subject.meshBirth Weight, drug effectsen_US
dc.subject.meshFetal Death, chemically induceden_US
dc.subject.meshFetus, drug effects, physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshAnimalsen_US
dc.titleInhibition of fetal growth and survival by testosterone administration to pregnant sheepen_US
dc.typeArticleen_US


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