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A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse

Show simple item record Baumgartner, James W. en_US Schuh, Sonya M. en_US Steiner, Robert A. en_US Clifton, Donald K. en_US Krasnow, Stephanie M. en_US Fraley, Gregory S. en_US 2008-10-17T20:42:15Z 2008-10-17T20:42:15Z 2003-03 en_US
dc.identifier.citation Endocrinology. 2003 Mar;144(3):813-22 en_US
dc.description.abstract Galanin-like peptide (GALP) shares sequence homology with galanin and binds to galanin receptors in vitro. GALP neurons in the arcuate nucleus coexpress leptin receptors, and GALP mRNA expression is up-regulated by leptin. Based on these observations, we postulated that GALP plays a role in mediating leptin's inhibitory effects on food intake (FI) and body weight (BW), as well as its stimulatory effect on the reproductive axis. To test these hypotheses, we performed several studies in which mice received intracerebroventricular injections of either GALP or vehicle. Acute GALP treatment elicited a dose-dependent suppression of FI and BW. Long-term treatment with GALP caused only transient reductions in FI and BW, demonstrating that the mice became refractory to continued exposure to GALP. GALP inhibited FI as early as 1 h post injection. Central injection of GALP suppressed locomotor activity and elicited the formation of a conditioned taste aversion. In male mice, serum levels of LH and testosterone were increased by GALP administration. Although we cannot rule out possible nonspecific effects of GALP on FI, the present observations are consistent with the argument that GALP is a downstream effector of leptin's actions within the central nervous system. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject body weight en_US
dc.subject GALP en_US
dc.subject food intake en_US
dc.subject leptin en_US
dc.subject.mesh Injections, Intraventricular en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Taste en_US
dc.subject.mesh Galanin-Like Peptide en_US
dc.subject.mesh Leptin, pharmacology en_US
dc.subject.mesh Male en_US
dc.subject.mesh Kinetics en_US
dc.subject.mesh Conditioning (Psychology) en_US
dc.subject.mesh Nerve Tissue Proteins, administration & dosage, pharmacology, physiology en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Mice, Inbred C57BL en_US
dc.subject.mesh Rats, Sprague-Dawley en_US
dc.subject.mesh Luteinizing Hormone, blood en_US
dc.subject.mesh Eating, physiology en_US
dc.subject.mesh Follicle Stimulating Hormone, blood en_US
dc.subject.mesh Dose-Response Relationship, Drug en_US
dc.subject.mesh Motor Activity, drug effects en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Testosterone, blood en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Body Weight en_US
dc.subject.mesh Reproduction, physiology en_US
dc.subject.mesh Rats en_US
dc.title A role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouse en_US
dc.type Article en_US

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