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dc.contributor.authorBaumgartner, James W.en_US
dc.contributor.authorSchuh, Sonya M.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorKrasnow, Stephanie M.en_US
dc.contributor.authorFraley, Gregory S.en_US
dc.date.accessioned2008-10-17T20:42:15Z
dc.date.available2008-10-17T20:42:15Z
dc.date.issued2003-03en_US
dc.identifier.citationEndocrinology. 2003 Mar;144(3):813-22en_US
dc.identifier.urihttp://hdl.handle.net/1773/4407
dc.description.abstractGalanin-like peptide (GALP) shares sequence homology with galanin and binds to galanin receptors in vitro. GALP neurons in the arcuate nucleus coexpress leptin receptors, and GALP mRNA expression is up-regulated by leptin. Based on these observations, we postulated that GALP plays a role in mediating leptin's inhibitory effects on food intake (FI) and body weight (BW), as well as its stimulatory effect on the reproductive axis. To test these hypotheses, we performed several studies in which mice received intracerebroventricular injections of either GALP or vehicle. Acute GALP treatment elicited a dose-dependent suppression of FI and BW. Long-term treatment with GALP caused only transient reductions in FI and BW, demonstrating that the mice became refractory to continued exposure to GALP. GALP inhibited FI as early as 1 h post injection. Central injection of GALP suppressed locomotor activity and elicited the formation of a conditioned taste aversion. In male mice, serum levels of LH and testosterone were increased by GALP administration. Although we cannot rule out possible nonspecific effects of GALP on FI, the present observations are consistent with the argument that GALP is a downstream effector of leptin's actions within the central nervous system.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectbody weighten_US
dc.subjectGALPen_US
dc.subjectfood intakeen_US
dc.subjectleptinen_US
dc.subject.meshInjections, Intraventricularen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshTasteen_US
dc.subject.meshGalanin-Like Peptideen_US
dc.subject.meshLeptin, pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshKineticsen_US
dc.subject.meshConditioning (Psychology)en_US
dc.subject.meshNerve Tissue Proteins, administration & dosage, pharmacology, physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshEating, physiologyen_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshMotor Activity, drug effectsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshTestosterone, blooden_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshBody Weighten_US
dc.subject.meshReproduction, physiologyen_US
dc.subject.meshRatsen_US
dc.titleA role for galanin-like peptide in the integration of feeding, body weight regulation, and reproduction in the mouseen_US
dc.typeArticleen_US


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