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Follicle-stimulating hormone is required for quantitatively normal inhibin secretion in men

Show simple item record de Kretser, David M. en_US Burger, Henry G. en_US Bremner, William J. en_US McLachlan, Robert I. en_US Matsumoto, Alvin M. en_US 2008-10-17T20:42:16Z 2008-10-17T20:42:16Z 1988-12 en_US
dc.identifier.citation J Clin Endocrinol Metab. 1988 Dec;67(6):1305-8 en_US
dc.description.abstract Inhibin is a glycoprotein hormone produced by the testis and ovary which is postulated to be an important regulator of pituitary FSH secretion. Animal data indicate that inhibin is produced by the Sertoli cells of the testis under the influence of FSH. To determine the role of FSH withdrawal and replacement in the control of inhibin secretion in man, we measured serum inhibin concentrations in men in whom isolated FSH deficiency had been produced by chronic hCG administration; this was followed by FSH replacement. After a 3-month control period, four normal men received hCG for 7 months, resulting in suppression of serum FSH to undetectable levels and urinary FSH excretion to prepubertal levels. Their mean serum inhibin levels fell to 70% of control values during hCG administration [362 +/- 60 (+/- SE) vs. 518 +/- 56 U/L; P less than 0.01]. While continuing hCG, testosterone enanthate was administered for a further 6 months. Serum FSH and inhibin levels remained suppressed to a similar degree. Testosterone administration then was ceased, and hCG continued for a further 2-4 months. Then, while continuing hCG administration, FSH was replaced as either highly purified human FSH (n = 2) or human menopausal gonadotropin (n = 2) for a period of 4-10 months. Serum FSH levels increased to the mid- and upper normal male ranges, respectively. FSH replacement restored serum inhibin levels to 522 +/- 56 U/L (P = NS vs. control). In summary, prolonged selective FSH deficiency induced by chronic hCG administration suppressed inhibin secretion. Replacement of FSH activity restored inhibin secretion to control values. We conclude that 1) FSH is not absolutely required for inhibin secretion in men; and 2) the maintenance of quantitatively normal inhibin secretion requires the combined action of both gonadotropins. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject male contraception en_US
dc.subject andrology en_US
dc.subject gonadotropins en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject spermatogenesis en_US
dc.subject testosterone en_US
dc.subject colchicine en_US
dc.subject klinefelter's syndrome en_US
dc.subject reifenstein's syndrome en_US
dc.subject.mesh Follicle Stimulating Hormone, deficiency, pharmacology, physiology en_US
dc.subject.mesh Drug Interactions en_US
dc.subject.mesh Male en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Inhibins, blood, secretion en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Sperm Count, drug effects en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Chorionic Gonadotropin, pharmacology en_US
dc.subject.mesh Testosterone, analogs & derivatives, pharmacology en_US
dc.title Follicle-stimulating hormone is required for quantitatively normal inhibin secretion in men en_US
dc.type Article en_US

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