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Prostate-sparing effects in primates of the potent androgen 7alpha-methyl-19-nortestosterone: a potential alternative to testosterone for androgen replacement and male contraception

Show simple item record Sundaram, Kalyan en_US Bardin, C. Wayne en_US Bremner, William J. en_US Cummings, David E. en_US Kumar, Narender en_US 2008-10-17T20:42:18Z 2008-10-17T20:42:18Z 1998-12 en_US
dc.identifier.citation J Clin Endocrinol Metab. 1998 Dec;83(12):4212-9 en_US
dc.description.abstract 7alpha-Methyl-19-nortestosterone (MENT) is a potent synthetic androgen that cannot be converted to dihydrotestosterone. In this study we determined the relative androgenic, antigonadotropic, and anabolic potencies of testosterone vs. MENT in the nonhuman primate M. fascicularis. In castrated monkeys, dose-response relationships were generated for the effects of testosterone and MENT on gonadotropin levels, prostate growth, body weight, and lipid metabolism. In a pilot study, four monkeys were castrated, and magnetic resonance imaging (MRI) was used to document a 50% loss of prostate volume within 8 weeks, verifying that MRI is a reliable means to measure prostate size in this species. Two additional groups of six monkeys each were then castrated and serially administered four graded dosages of testosterone or MENT via osmotic minipumps over 20 weeks. Complete suppression of LH was achieved with a minimum of 0.3 mg/day MENT, compared to 3.0 mg/day testosterone. MENT supported body weight 10 times more potently than did testosterone. Baseline prostate volumes were maintained with 0.1-0.2 mg/day MENT vs. 0.3 mg/day testosterone. Thus, in monkeys, MENT is 10 times more potent than testosterone with regard to the clinically desirable end points of gonadotropin suppression and anabolism, but only twice as potent at stimulating prostate growth. These results suggest that MENT may have a wider therapeutic index than testosterone for human androgen replacement and male contraception. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject male contraception en_US
dc.subject andrology en_US
dc.subject gonadotropins en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject spermatogenesis en_US
dc.subject testosterone en_US
dc.subject colchicine en_US
dc.subject klinefelter's syndrome en_US
dc.subject reifenstein's syndrome en_US
dc.subject.mesh Body Weight, drug effects en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Contraceptive Agents, Male, pharmacology en_US
dc.subject.mesh Hormone Replacement Therapy en_US
dc.subject.mesh Comparative Study en_US
dc.subject.mesh Male en_US
dc.subject.mesh Luteinizing Hormone, antagonists & inhibitors en_US
dc.subject.mesh Macaca fascicularis en_US
dc.subject.mesh Orchiectomy en_US
dc.subject.mesh Dose-Response Relationship, Drug en_US
dc.subject.mesh Anabolic Agents, pharmacology en_US
dc.subject.mesh Androgens, metabolism en_US
dc.subject.mesh Magnetic Resonance Imaging en_US
dc.subject.mesh Testosterone, pharmacology, therapeutic use en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Prostate, anatomy & histology, drug effects, growth & development en_US
dc.subject.mesh Nandrolone, analogs & derivatives, pharmacology en_US
dc.title Prostate-sparing effects in primates of the potent androgen 7alpha-methyl-19-nortestosterone: a potential alternative to testosterone for androgen replacement and male contraception en_US
dc.type Article en_US

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