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dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorGottsch, Michelle L.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.date.accessioned2008-10-17T20:42:24Z
dc.date.available2008-10-17T20:42:24Z
dc.date.issued2004-07en_US
dc.identifier.citationTrends Endocrinol Metab. 2004 Jul;15(5):215-21en_US
dc.identifier.urihttp://hdl.handle.net/1773/4417
dc.description.abstractThe arcuate nucleus is a hypothalamic center that couples energetics and reproduction. Peptide-releasing neurons in the arcuate nucleus receive and process humoral signals from the periphery and relay this information to other nuclei in the hypothalamus and preoptic area. Galanin-like peptide (GALP) is expressed in the arcuate nucleus, and GALP-containing neurons are targets for the action of leptin. GALP-containing neurons are closely apposed to gonadotropin-releasing hormone (GnRH) neurons in the preoptic area, and CNS injections of GALP stimulate GnRH-mediated secretion of luteinizing hormone. These observations indicate that GALP is a molecular signal that couples circulating indices of metabolism to the neuroendocrine reproductive system and, thus, regulates reproductive activity as a function of the energy state. In this article, we describe the involvement of GALP in metabolism and reproduction, and in the coupling between these two processes.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectarcuate nucleusen_US
dc.subjectmetabolismen_US
dc.subjectreproductionen_US
dc.subjectgalanin-like peptideen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshGalanin-Like Peptide, metabolismen_US
dc.subject.meshEnergy Metabolism, physiologyen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshReproduction, physiologyen_US
dc.titleGalanin-like peptide as a link in the integration of metabolism and reproductionen_US
dc.typeArticleen_US


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