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dc.contributor.authorBremner, William J.en_US
dc.contributor.authorZhang, Gui-Yuanen_US
dc.contributor.authorGu, Yi-Qunen_US
dc.contributor.authorGe, Zheng-Yanen_US
dc.date.accessioned2008-10-17T20:42:34Z
dc.date.available2008-10-17T20:42:34Z
dc.date.issued2000-03en_US
dc.identifier.citationAsian J Androl. 2000 Mar;2(1):65-71en_US
dc.identifier.urihttp://hdl.handle.net/1773/4427
dc.description.abstractAIM: To clarify the immuno-active LH (i-LH) and bioactive LH (b-LH) responses and qualitative changes in the circulating LH to testosterone undecanoate (TU) injection. METHODS: Eight men with Klinefelter's syndrome were recruited for the study. They received crossover injections of TU at doses of 500 and 1000 mg. Serum i-LH and b-LH levels before and at various time intervals after TU injection were measured and the serum i-LH, b-LH, b-LH/i-LH (B/I) and testosterone/sex hormone-binding globulin (T/SHBG) ratio in LH-responders and LH non-responders were compared. RESULTS: A parallel suppression of serum i-LH and b-LH was consistent with their overall high correlation between each other (r = 0.84, P < 0.001). Mean serum i-FSH levels were decreased by TU injection at both doses without dose-response effects. LH-responders had lower baseline serum i-LH and b-LH, and higher E2 levels and T/SHBG ratio. There was a quantitative change in serum LH as induced by TU without qualitative change within LH-responders os LH-non-responders. CONCLUSION: A high loading dose (1000 mg) of TU is important for the initial suppression of LH. With the lower dose (500 mg), repeated injections will be required to attain such LH suppression for the purpose of fertility regulation. The lower baseline serum i-LH level may be an intrinsic characteristic of LH-responders.en_US
dc.language.isoen_USen_US
dc.publisherBlackwell Publishingen_US
dc.subjectLHen_US
dc.subjectbioactivityen_US
dc.subjecttestosteroneen_US
dc.subjectestrogenen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshKlinefelter Syndrome, blooden_US
dc.subject.meshProlactin, blooden_US
dc.subject.meshTestosterone, analogs & derivatives, pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshAdolescenten_US
dc.subject.meshEstradiol, blooden_US
dc.subject.meshAdulten_US
dc.subject.meshSex Hormone-Binding Globulin, analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshInjectionsen_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshCross-Over Studiesen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.titleQuantitative and qualitative changes in serum luteinizing hormone after injectable testosterone undecanoate treatment in hypogonadal menen_US
dc.typeArticleen_US


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