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Bone mineral content of amenorrheic and eumenorrheic athletes

Show simple item record Bremner, William J. en_US Chesnut, III, Charles H. en_US Southworth, Molly B. en_US Shainholtz, Sydney en_US Drinkwater, Barbara L. en_US Nilson, Karen en_US 2008-10-17T20:42:49Z 2008-10-17T20:42:49Z 1984-08-02 en_US
dc.identifier.citation N Engl J Med. 1984 Aug 2;311(5):277-81 en_US
dc.description.abstract This study was designed to determine whether the hypoestrogenic status of 14 amenorrheic athletes was associated with a decrease in regional bone mass relative to that of 14 of their eumenorrheic peers. The two groups of athletes were matched for age, height, weight, sport, and training regimens. Bone mass was measured by dual-photon and single-photon absorptiometry at the lumbar vertebrae (L1 to L4) and at two sites on the radius. Vertebral mineral density was significantly lower in the amenorrheic group (mean, 1.12 g per square centimeter) than in the eumenorrheic group (mean, 1.30 g per square centimeter). There was no significant difference at either radial site. Radioimmunoassay confirmed a lower mean estradiol concentration (amenorrheic group, 38.58 pg per milliliter; eumenorrheic group, 106.99 pg per milliliter) and progesterone peak (amenorrheic group, 1.25 ng per milliliter; eumenorrheic group, 12.75 ng per milliliter) in the amenorrheic women, in four venous samples drawn at seven-day intervals. A three-day dietary history showed no significant differences in nutritional intake, including calcium with and without supplements. The two groups were similar in percentage of body fat, age at menarche, years of athletic participation, and frequency and duration of training but differed in number of miles run per week (amenorrheic group, 41.8 miles [67.3 km]; eumenorrheic group, 24.9 miles [40.1 km]). We conclude that the amenorrhea that is observed in female athletes may be accompanied by a decrease in mineral density of the lumbar vertebrae. en_US
dc.language.iso en_US en_US
dc.publisher Massachusetts Medical Society en_US
dc.subject male contraception en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject andrology en_US
dc.subject reifenstein's syndrome en_US
dc.subject gonadotropins en_US
dc.subject colchicine en_US
dc.subject spermatogenesis en_US
dc.subject testosterone en_US
dc.subject klinefelter's syndrome en_US
dc.subject.mesh Bone and Bones, analysis en_US
dc.subject.mesh Testosterone, blood en_US
dc.subject.mesh Amenorrhea, blood, metabolism en_US
dc.subject.mesh Estradiol, blood en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Diet en_US
dc.subject.mesh Prolactin, blood en_US
dc.subject.mesh Menstruation en_US
dc.subject.mesh Minerals, analysis en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Female en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Progesterone, blood en_US
dc.subject.mesh Sports en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.title Bone mineral content of amenorrheic and eumenorrheic athletes en_US
dc.type Article en_US

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