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dc.contributor.authorBremner, William J.en_US
dc.contributor.authorChesnut, III, Charles H.en_US
dc.contributor.authorSouthworth, Molly B.en_US
dc.contributor.authorShainholtz, Sydneyen_US
dc.contributor.authorDrinkwater, Barbara L.en_US
dc.contributor.authorNilson, Karenen_US
dc.date.accessioned2008-10-17T20:42:49Z
dc.date.available2008-10-17T20:42:49Z
dc.date.issued1984-08-02en_US
dc.identifier.citationN Engl J Med. 1984 Aug 2;311(5):277-81en_US
dc.identifier.urihttp://hdl.handle.net/1773/4440
dc.description.abstractThis study was designed to determine whether the hypoestrogenic status of 14 amenorrheic athletes was associated with a decrease in regional bone mass relative to that of 14 of their eumenorrheic peers. The two groups of athletes were matched for age, height, weight, sport, and training regimens. Bone mass was measured by dual-photon and single-photon absorptiometry at the lumbar vertebrae (L1 to L4) and at two sites on the radius. Vertebral mineral density was significantly lower in the amenorrheic group (mean, 1.12 g per square centimeter) than in the eumenorrheic group (mean, 1.30 g per square centimeter). There was no significant difference at either radial site. Radioimmunoassay confirmed a lower mean estradiol concentration (amenorrheic group, 38.58 pg per milliliter; eumenorrheic group, 106.99 pg per milliliter) and progesterone peak (amenorrheic group, 1.25 ng per milliliter; eumenorrheic group, 12.75 ng per milliliter) in the amenorrheic women, in four venous samples drawn at seven-day intervals. A three-day dietary history showed no significant differences in nutritional intake, including calcium with and without supplements. The two groups were similar in percentage of body fat, age at menarche, years of athletic participation, and frequency and duration of training but differed in number of miles run per week (amenorrheic group, 41.8 miles [67.3 km]; eumenorrheic group, 24.9 miles [40.1 km]). We conclude that the amenorrhea that is observed in female athletes may be accompanied by a decrease in mineral density of the lumbar vertebrae.en_US
dc.language.isoen_USen_US
dc.publisherMassachusetts Medical Societyen_US
dc.subjectmale contraceptionen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectandrologyen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectgonadotropinsen_US
dc.subjectcolchicineen_US
dc.subjectspermatogenesisen_US
dc.subjecttestosteroneen_US
dc.subjectklinefelter's syndromeen_US
dc.subject.meshBone and Bones, analysisen_US
dc.subject.meshTestosterone, blooden_US
dc.subject.meshAmenorrhea, blood, metabolismen_US
dc.subject.meshEstradiol, blooden_US
dc.subject.meshHumansen_US
dc.subject.meshDieten_US
dc.subject.meshProlactin, blooden_US
dc.subject.meshMenstruationen_US
dc.subject.meshMinerals, analysisen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshFemaleen_US
dc.subject.meshAdulten_US
dc.subject.meshProgesterone, blooden_US
dc.subject.meshSportsen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.titleBone mineral content of amenorrheic and eumenorrheic athletesen_US
dc.typeArticleen_US


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