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dc.contributor.authorUgoni, Antonyen_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorPruysers, Eniden_US
dc.contributor.authorMeriggiola, M. Cristinaen_US
dc.contributor.authorAnawalt, Bradley D.en_US
dc.contributor.authorMatsumoto, Alvin M.en_US
dc.contributor.authorMcLachlan, Robert I.en_US
dc.contributor.authorRobertson, David M.en_US
dc.date.accessioned2008-10-17T20:42:52Z
dc.date.available2008-10-17T20:42:52Z
dc.date.issued2004-01en_US
dc.identifier.citationJ Clin Endocrinol Metab. 2004 Jan;89(1):142-9en_US
dc.identifier.urihttp://hdl.handle.net/1773/4443
dc.description.abstractThis study aimed to establish whether the degree of suppression of serum FSH and LH was related to sperm concentration in three testosterone (T) plus progestin contraceptive regimens. We measured serum FSH and LH using a modified, highly sensitive immunofluorometric assay in samples obtained from three published studies using T enanthate (TE; 100 and 200 mg weekly) plus daily oral doses of cyproterone acetate (CPA; 5-100 mg), levonogestrel (LNG; 150-500 micro g), or desogestrel (DSG; 150-300 micro g). Overall, men with sperm concentrations below 0.1 million/ml had significantly lower gonadotropin levels (serum FSH, approximately 0.12 IU/liter; serum LH, approximately 0.05 IU/liter) than oligospermic men (sperm concentrations, 0.1-5 million/ml; serum FSH, 0.23-0.5 IU/liter; serum LH, 0.05-0.56 IU/liter), but the relationship was weak, indicating the possible existence of other determinants. Multivariate logistic regression was used to identify the influence of candidate predictors of spermatogenic effects of the T plus progestin regimens. In the LNG and DSG studies, the marked suppression of serum LH to less than 5% of baseline values (<0.15 IU/liter) was a consistent and highly significant predictor of sperm concentration (reduced to 2-7% that seen at higher LH levels) and the likelihood of its suppression below 1 million/ml (a proposed threshold for contraceptive efficacy). Serum FSH was not a significant independent predictor. The use of DSG and CPA (but not LNG) was a significant independent predictor of sperm suppression, and regimens that contained 200 mg TE weekly caused less spermatogenic suppression than 100 mg TE weekly. These findings suggest that T-progestin contraceptive regimens suppress sperm concentration by gonadotropin-dependent and -independent mechanisms. The suppression of serum LH is a major predictor of the suppression of sperm concentration suppression in the LNG and DSG treatment studies. On the other hand, the greater spermatogenic suppression in regimens containing DSG or CPA suggests that these progestins have additional actions to suppress spermatogenesis via a gonadotropin-independent mechanism(s)en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectcolchicineen_US
dc.subjectmale contraceptionen_US
dc.subjecttestosteroneen_US
dc.subjectandrologyen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectspermatogenesisen_US
dc.subjectklinefelter's syndromeen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectgonadotropinsen_US
dc.subject.meshContraceptive Agents, Male, administration & dosageen_US
dc.subject.meshTestosterone, administration & dosage, analogs & derivativesen_US
dc.subject.meshDesogestrel, administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshCyproterone Acetate, administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshLevonorgestrel, administration & dosageen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshSpermatogenesis, drug effectsen_US
dc.subject.meshSperm Counten_US
dc.subject.meshProgestins, administration & dosageen_US
dc.titleRelationship between serum gonadotropins and spermatogenic suppression in men undergoing steroidal contraceptive treatmenten_US
dc.typeArticleen_US


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