Treatment of stage D2 prostatic carcinoma with combined gonadal and adrenal suppression in a 60-year-old man
Abstract
A 60-year-old man with stage D2 prostatic carcinoma received treatment
with a new luteinizing hormone-releasing hormone superagonist. After a
seven-month remission; relapse of the disease occurred and an
adrenal-suppressing dose of dexamethasone was added. The resulting
combined gonadal and adrenal suppression led to another remission that
lasted five months. This case supports other observations of the
importance of adrenal androgen production in the pathobiology of prostatic
carcinoma.