Molecular engineering
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Recent Submissions
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Zwitterlation improves efficacy and safety of therapeutic proteins
During the past decades, engineered proteins have been widely used as biopharmaceutical drugs (e.g., recombinant therapeutic proteins, enzymes, and monoclonal antibodies) and gene editing tools (e.g., zinc fingers, TALENs ... -
Software Algorithms for Design of Symmetric Protein Complexes Applied to Cryo-Electron Microscopy Scaffolds and Antibody Nanoparticles
Innovation in the symmetric assembly and protein material design space has the potential to – eventually – reinvent medicine and nanotechnology. One leading strategy for design of symmetric assemblies uses genetic fusion ... -
CRISPR-Cas activation for regulating multi-gene expression in bacteria
Bacterial metabolism is comprised of large and complex gene networks that can produce valuable chemical products. In principle, these networks can be reengineered using synthetic multi-gene transcriptional programs to ... -
High Resolution Measurements of RNA Polymerase with Nanopore Tweezers
RNA polymerase (RNAP) is the molecular machine responsible for transcription, the process of making RNA from a DNA template. While the overall role of RNAP in this central cellular process is clear (RNAP moves along double ... -
From Solvate to Cell: A Molecular Engineering Approach to the Lithium-Sulfur Battery
The lithium-sulfur (Li-S) battery system has been widely lauded as a candidate to replace lithium-ion (Li-ion) technology in weight-critical applications such as electric vehicles, aerospace missions, and personal electronics. ... -
Characterization of combustion generated particulate matter produced in an inverted gravity flame reactor
Many unknowns remain in the pursuit to describe the formation of combustion generated particles from first principles. Of most importance in the following thesis is the transition from young to mature soot that is evident ... -
Synthesis and Electrochemical Cycling Characteristics of Nanostructured Antimony Alloying Electrodes for Energy Storage Applications
Nanostructured antimony is a highly promising alloying electrode material for both Li-ion and Na-ion battery systems, possessing a large gravimetric charge storage capacity (660 mAh g-1) combined with extraordinary rate ... -
De Novo Design of Self-assembling Helical Protein Filaments
There has been some success in designing stable peptide filaments; however, mimicking the controllable and reversible assembly of many natural protein filaments is challenging. We devised a general computational approach ...
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