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dc.contributor.authorBartfai, Tamasen_US
dc.contributor.authorHohmann, John G.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorXu, Zhi-Qing D.en_US
dc.contributor.authorXu, Xiao-Junen_US
dc.contributor.authorHolmberg, Kristinaen_US
dc.contributor.authorBlakeman, Karin H.en_US
dc.contributor.authorHokfelt, Tomasen_US
dc.contributor.authorMufson, Elliott J.en_US
dc.contributor.authorCrawley, Jacqueline N.en_US
dc.contributor.authorWiesenfeld-Hallin, Zsuzsannaen_US
dc.contributor.authorTeklemichael, Dawit N.en_US
dc.date.accessioned2008-10-17T20:42:59Z
dc.date.available2008-10-17T20:42:59Z
dc.date.issued2002-04en_US
dc.identifier.citationNeuropeptides. 2002 Apr-Jun;36(2-3):145-56en_US
dc.identifier.urihttp://hdl.handle.net/1773/4451
dc.description.abstractGalanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT). Performance deficits on learning and memory tasks, impaired long-term potentiation, reduced hippocampal excitability, lower evoked glutamate release, and reduced numbers of choline acetyltransferase immunoreactive neurons in the horizontal limb of the diagonal band were detected in GAL-tg as compared to WT. Changes in sensitivity to nociceptive stimuli were demonstrated in one line. GAL-tg represent a new model for investigating the biological actions of endogenous galanin, and for testing novel therapeutics based on galanin receptor ligands.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectgalaninen_US
dc.subjectgalanin receptoren_US
dc.subjecttransgenicen_US
dc.subjectmiceen_US
dc.subject.meshSeizures, geneticsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshAnimalsen_US
dc.subject.meshGalanin, biosynthesis, geneticsen_US
dc.subject.meshAnxiety, genetics, psychologyen_US
dc.subject.meshAnalgesiaen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshNeurons, physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMutationen_US
dc.subject.meshMemory, physiologyen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshLearning, physiologyen_US
dc.titleGalanin overexpressing transgenic miceen_US
dc.typeArticleen_US


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