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Galanin overexpressing transgenic mice

Show simple item record Bartfai, Tamas en_US Hohmann, John G. en_US Steiner, Robert A. en_US Xu, Zhi-Qing D. en_US Xu, Xiao-Jun en_US Holmberg, Kristina en_US Blakeman, Karin H. en_US Hokfelt, Tomas en_US Mufson, Elliott J. en_US Crawley, Jacqueline N. en_US Wiesenfeld-Hallin, Zsuzsanna en_US Teklemichael, Dawit N. en_US 2008-10-17T20:42:59Z 2008-10-17T20:42:59Z 2002-04 en_US
dc.identifier.citation Neuropeptides. 2002 Apr-Jun;36(2-3):145-56 en_US
dc.description.abstract Galanin overexpressing transgenic mice (GAL-tg) were generated on two different promoters. Both lines of GAL-tg displayed high levels of galanin in the hippocampus and reduced sensitivity to seizures, as compared to their respective wildtype littermate controls (WT). Performance deficits on learning and memory tasks, impaired long-term potentiation, reduced hippocampal excitability, lower evoked glutamate release, and reduced numbers of choline acetyltransferase immunoreactive neurons in the horizontal limb of the diagonal band were detected in GAL-tg as compared to WT. Changes in sensitivity to nociceptive stimuli were demonstrated in one line. GAL-tg represent a new model for investigating the biological actions of endogenous galanin, and for testing novel therapeutics based on galanin receptor ligands. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject galanin en_US
dc.subject galanin receptor en_US
dc.subject transgenic en_US
dc.subject mice en_US
dc.subject.mesh Seizures, genetics en_US
dc.subject.mesh Phenotype en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Galanin, biosynthesis, genetics en_US
dc.subject.mesh Anxiety, genetics, psychology en_US
dc.subject.mesh Analgesia en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Neurons, physiology en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Mutation en_US
dc.subject.mesh Memory, physiology en_US
dc.subject.mesh Mice, Transgenic en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Learning, physiology en_US
dc.title Galanin overexpressing transgenic mice en_US
dc.type Article en_US

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