Testosterone administration suppresses adiponectin levels in men

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Testosterone administration suppresses adiponectin levels in men

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dc.contributor.author Coviello, Andrea D. en_US
dc.contributor.author Bremner, William J. en_US
dc.contributor.author Amory, John K. en_US
dc.contributor.author Matsumoto, Alvin M. en_US
dc.contributor.author Anawalt, Bradley D. en_US
dc.contributor.author Page, Stephanie T. en_US
dc.contributor.author Herbst, Karen L. en_US
dc.date.accessioned 2008-10-17T20:43:05Z
dc.date.available 2008-10-17T20:43:05Z
dc.date.issued 2005-01 en_US
dc.identifier.citation J Androl. 2005 Jan-Feb;26(1):85-92 en_US
dc.identifier.uri http://hdl.handle.net/1773/4457
dc.description.abstract Testosterone (T) administration to men increases lean body mass and decreases fat mass. Adiponectin is produced by adipocytes and is thought to influence insulin sensitivity. In this study, we sought to determine whether experimental alterations in serum T change adiponectin levels in normal men. We measured adiponectin levels in 28 healthy men ages 18-35 years before and during treatment with a potent gonadotropin-releasing-hormone (GnRH) antagonist, acyline. Decreased T levels led to increased serum adiponectin within 7 days; maximal adiponectin levels were reached on day 21 (baseline 8.6 +/- 0.9 compared with 12.2 +/- 1.0 microg/mL on day 21, P <.05) and persisted through day 30, despite no significant changes in body mass index (BMI) and an increase in leptin. The addition of T to acyline, maintaining serum T levels within the normal range, prevented the increase in adiponectin following acyline alone. In a second study, 25 men aged 55-85 years were treated with 3 weeks of high-dose T (testosterone enanthate [TE], 600 mg/wk intramuscularly). With high serum T levels, adiponectin levels decreased significantly by day 21 of treatment (baseline 14.3 +/- 1.9 compared with 10.8 +/- 1.5 microg/mL, P <.05 vs baseline and placebo), BMI slightly increased, and leptin levels were decreased. We conclude that adiponectin levels increase within days of experimental T deficiency in normal men, and the increase in adiponectin is prevented by T replacement. Furthermore, supraphysiologic T administration results in decreased adiponectin levels. Our data support the hypothesis that T, its metabolites, or both directly suppress adipocyte production of adiponectin. en_US
dc.language.iso en_US en_US
dc.publisher American Society of Andrology en_US
dc.subject hypogonadal en_US
dc.subject androgen en_US
dc.subject leptin en_US
dc.subject.mesh Gonadorelin, antagonists & inhibitors en_US
dc.subject.mesh Comparative Study en_US
dc.subject.mesh Intercellular Signaling Peptides and Proteins, blood en_US
dc.subject.mesh Male en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Adult en_US
dc.subject.mesh Testosterone, blood, deficiency, pharmacology en_US
dc.subject.mesh Middle Aged en_US
dc.subject.mesh Oligopeptides, pharmacology en_US
dc.subject.mesh Leptin, blood en_US
dc.subject.mesh Aged, 80 and over en_US
dc.subject.mesh Body Mass Index en_US
dc.subject.mesh Aged en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Adiponectin en_US
dc.subject.mesh Adolescent en_US
dc.title Testosterone administration suppresses adiponectin levels in men en_US
dc.type Article en_US


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