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dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorThornton, Janice E.en_US
dc.contributor.authorCheung, Clement C.en_US
dc.date.accessioned2008-10-17T20:43:17Z
dc.date.available2008-10-17T20:43:17Z
dc.date.issued1997-11en_US
dc.identifier.citationEndocrinology. 1997 Nov;138(11):5063-6en_US
dc.identifier.urihttp://hdl.handle.net/1773/4466
dc.description.abstractThe hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which are derived from the precursor proopiomelanocortin (POMC), are also implicated in the physiological regulation of body weight. POMC-containing neurons express the leptin receptor, and thus it is conceivable that the POMC gene itself may be part of the signaling pathway involved in leptin's action on the brain. Using in situ hybridization and computerized image analysis, we tested the hypothesis that the POMC gene is a target for regulation by leptin by comparing cellular levels of POMC mRNA in the hypothalamus among groups of leptin-deficient (ob/ob) mice, leptin-treated ob/ob mice, and wild-type controls. POMC mRNA levels were significantly reduced throughout the arcuate nucleus in vehicle-treated ob/ob mice relative to wild-type controls, whereas POMC mRNA levels in leptin-treated ob/ob mice were indistinguishable from wild-type controls. These observations suggest that one or more products of POMC serve as an integrative link between leptin and the central mechanisms governing body weight regulation and reproduction.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectleptin receptoren_US
dc.subjectPOMC mRNAen_US
dc.subjectin situ hybridizationen_US
dc.subjectbody weighten_US
dc.subject.meshObesity, genetics, metabolism, pathologyen_US
dc.subject.meshNeurons, metabolism, pathologyen_US
dc.subject.meshProteins, genetics, metabolism, pharmacologyen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshPro-Opiomelanocortin, geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshLeptinen_US
dc.subject.meshCell Counten_US
dc.subject.meshRNA, Messenger, metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Mutant Strains, geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshEating, drug effectsen_US
dc.subject.meshHypothalamus, metabolism, pathologyen_US
dc.titleRegulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob miceen_US
dc.typeArticleen_US


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