Testosterone delivery using glutamide-based complex high axial ratio microstructures

ResearchWorks/Manakin Repository

Search ResearchWorks


Advanced Search

Browse

My Account

Statistics

Related Information

Testosterone delivery using glutamide-based complex high axial ratio microstructures

Show simple item record

dc.contributor.author Matsumoto, Alvin M. en_US
dc.contributor.author Yager, Paul en_US
dc.contributor.author Amory, John K. en_US
dc.contributor.author Goldstein, Alex S. en_US
dc.contributor.author Vernon, Chris en_US
dc.contributor.author Martin, Stephanie M. en_US
dc.date.accessioned 2008-10-17T20:43:22Z
dc.date.available 2008-10-17T20:43:22Z
dc.date.issued 2001-11 en_US
dc.identifier.citation Bioorg Med Chem. 2001 Nov;9(11):2819-25 en_US
dc.identifier.uri http://hdl.handle.net/1773/4470
dc.description.abstract Complex high axial ratio microstructures (CHARMs) were evaluated for delivery of testosterone in vivo. Methods to incorporate testosterone included noncovalent mixing and covalent attachment of testosterone to the lipid to form a prodrug monomer. When prepared by covalent attachment, testosterone-loaded CHARMs were resistant to in vitro spontaneous hydrolysis; when injected into rats, testosterone was released with biphasic kinetics consisting of a burst followed by a much slower phase. Some CHARM material associated with testosterone persisted at the site of injection for at least 9 days. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject male contraception en_US
dc.subject andrology en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject complex high axial ratio microstructures en_US
dc.subject CHARMS en_US
dc.subject gonadotropins en_US
dc.subject testosterone en_US
dc.subject.mesh Lipids, administration & dosage, chemistry, pharmacokinetics en_US
dc.subject.mesh Prodrugs, administration & dosage, pharmacokinetics en_US
dc.subject.mesh Rats en_US
dc.subject.mesh Testosterone, administration & dosage, blood, pharmacokinetics en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Microscopy, Electron en_US
dc.subject.mesh Delayed-Action Preparations en_US
dc.subject.mesh Surface-Active Agents, administration & dosage, chemistry, pharmacokinetics en_US
dc.subject.mesh Rats, Sprague-Dawley en_US
dc.subject.mesh Glutamine, analogs & derivatives, chemistry en_US
dc.subject.mesh Male en_US
dc.subject.mesh Injections en_US
dc.subject.mesh Drug Delivery Systems en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.title Testosterone delivery using glutamide-based complex high axial ratio microstructures en_US
dc.type Article en_US


Files in this item

Files Size Format View
BioorgMedChem_2001_Testosterone_Delivery.pdf 248.5Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record