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dc.contributor.authorMatsumoto, Alvin M.en_US
dc.contributor.authorBremner, William J.en_US
dc.date.accessioned2008-10-17T20:43:23Z
dc.date.available2008-10-17T20:43:23Z
dc.date.issued1985-05en_US
dc.identifier.citationJ Androl. 1985 May-Jun;6(3):137-43en_US
dc.identifier.urihttp://hdl.handle.net/1773/4471
dc.description.abstractThe precise hormonal milieu required for quantitatively normal spermatogenesis in man is unclear. The authors previously have shown that both supraphysiologic dosages of human chorionic gonadotropin (hCG) and physiologic dosages of human luteinizing hormone (hLH) can reinitiate sperm production in short-term (four months) gonadotropin-suppressed normal men who have prepubertal FSH levels. To determine whether normal FSH levels were necessary to stimulate sperm production after a prolonged period of gonadotropin and testicular suppression, the authors administered hCG to four normal men whose endogenous gonadotropin levels and sperm production were suppressed by prolonged exogenous testosterone (T) administration. After a 3-month control period, all subjects received 200 mg of T enanthate intramuscularly (im) each week to suppress LH and FSH for a total of 9 months and until successive sperm concentrations (performed twice monthly) revealed azoospermia or severe oligozoospermia (mean sperm concentration less than 3 X 10(6) spermatozoa/ml) for 6 months. Then, while continuing the same dosage of T enanthate, all four men simultaneously received 5000 IU of hCG im three times weekly for 6 months, replacing LH-like activity and leaving FSH activity suppressed. The effect on sperm production of the selective FSH deficiency produced by hCG plus T administration after the period of prolonged gonadotropin suppression was determined. Exogenous T administration resulted in severe suppression of sperm concentrations from 79 +/- 7 X 10(6) spermatozoa/ml (mean +/- SEM) during the control period to 0.8 +/- 0.5 X 10(6)/ml after 12 weeks of T treatment.(ABSTRACT TRUNCATED AT 250 WORDS)en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Andrologyen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectgonadotropinsen_US
dc.subjecttestosteroneen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectklinefelter's syndromeen_US
dc.subjectspermatogenesisen_US
dc.subjectandrologyen_US
dc.subjectmale contraceptionen_US
dc.subjectcolchicineen_US
dc.subject.meshMaleen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshSemen, drug effectsen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshChorionic Gonadotropin, pharmacologyen_US
dc.subject.meshSperm Countsen_US
dc.subject.meshSpermatogenesis, drug effectsen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshFollicle Stimulating Hormone, blood, urineen_US
dc.subject.meshHumansen_US
dc.subject.meshEstradiol, blooden_US
dc.subject.meshTestosterone, analogs & derivatives, blood, pharmacologyen_US
dc.subject.meshAdulten_US
dc.titleStimulation of sperm production by human chorionic gonadotropin after prolonged gonadotropin suppression in normal menen_US
dc.typeArticleen_US


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