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Stimulation of sperm production by human chorionic gonadotropin after prolonged gonadotropin suppression in normal men

Show simple item record Matsumoto, Alvin M. en_US Bremner, William J. en_US 2008-10-17T20:43:23Z 2008-10-17T20:43:23Z 1985-05 en_US
dc.identifier.citation J Androl. 1985 May-Jun;6(3):137-43 en_US
dc.description.abstract The precise hormonal milieu required for quantitatively normal spermatogenesis in man is unclear. The authors previously have shown that both supraphysiologic dosages of human chorionic gonadotropin (hCG) and physiologic dosages of human luteinizing hormone (hLH) can reinitiate sperm production in short-term (four months) gonadotropin-suppressed normal men who have prepubertal FSH levels. To determine whether normal FSH levels were necessary to stimulate sperm production after a prolonged period of gonadotropin and testicular suppression, the authors administered hCG to four normal men whose endogenous gonadotropin levels and sperm production were suppressed by prolonged exogenous testosterone (T) administration. After a 3-month control period, all subjects received 200 mg of T enanthate intramuscularly (im) each week to suppress LH and FSH for a total of 9 months and until successive sperm concentrations (performed twice monthly) revealed azoospermia or severe oligozoospermia (mean sperm concentration less than 3 X 10(6) spermatozoa/ml) for 6 months. Then, while continuing the same dosage of T enanthate, all four men simultaneously received 5000 IU of hCG im three times weekly for 6 months, replacing LH-like activity and leaving FSH activity suppressed. The effect on sperm production of the selective FSH deficiency produced by hCG plus T administration after the period of prolonged gonadotropin suppression was determined. Exogenous T administration resulted in severe suppression of sperm concentrations from 79 +/- 7 X 10(6) spermatozoa/ml (mean +/- SEM) during the control period to 0.8 +/- 0.5 X 10(6)/ml after 12 weeks of T treatment.(ABSTRACT TRUNCATED AT 250 WORDS) en_US
dc.language.iso en_US en_US
dc.publisher American Society of Andrology en_US
dc.subject 5-alpha reductase inhibitors en_US
dc.subject gonadotropins en_US
dc.subject testosterone en_US
dc.subject reifenstein's syndrome en_US
dc.subject klinefelter's syndrome en_US
dc.subject spermatogenesis en_US
dc.subject andrology en_US
dc.subject male contraception en_US
dc.subject colchicine en_US
dc.subject.mesh Male en_US
dc.subject.mesh Luteinizing Hormone, blood en_US
dc.subject.mesh Research Support, U.S. Gov't, Non-P.H.S. en_US
dc.subject.mesh Semen, drug effects en_US
dc.subject.mesh Radioimmunoassay en_US
dc.subject.mesh Chorionic Gonadotropin, pharmacology en_US
dc.subject.mesh Sperm Counts en_US
dc.subject.mesh Spermatogenesis, drug effects en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Follicle Stimulating Hormone, blood, urine en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Estradiol, blood en_US
dc.subject.mesh Testosterone, analogs & derivatives, blood, pharmacology en_US
dc.subject.mesh Adult en_US
dc.title Stimulation of sperm production by human chorionic gonadotropin after prolonged gonadotropin suppression in normal men en_US
dc.type Article en_US

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