dc.contributor.author | Cohen, Nancy L. | en_US |
dc.contributor.author | Steiner, Robert A. | en_US |
dc.contributor.author | Bremner, William J. | en_US |
dc.contributor.author | Soules, Michael R. | en_US |
dc.contributor.author | Clifton, Donald K. | en_US |
dc.date.accessioned | 2008-10-17T20:43:39Z | |
dc.date.available | 2008-10-17T20:43:39Z | |
dc.date.issued | 1988-05 | en_US |
dc.identifier.citation | Obstet Gynecol. 1988 May;71(5):659-66 | en_US |
dc.identifier.uri | http://hdl.handle.net/1773/4477 | |
dc.description.abstract | Fourteen normal volunteers were studied during one menstrual cycle.
Follicular development, the luteinizing hormone (LH) surge, and the
relationship between LH and progesterone secretion in the luteal phase
were studied to determine the factors that control corpus luteum function.
Follicular development was assessed by measuring follicle size and daily
estradiol (E2) levels; the LH surge was quantified by determining the area
under the curve. Although there was a significant positive correlation
between mean follicle diameter and E2, these same parameters did not
correlate with postovulatory progesterone secretion; nor did the LH surge
correlate with progesterone secretion. A decrease in LH pulse frequency
occurred in moving from the follicular to the luteal phase. There was a
trend toward an increase in the late luteal LH pulse frequency compared
with the midluteal phase, but this was not significant. Progesterone was
secreted in an intermittent (pulsatile) fashion in the midluteal and late
luteal phases. The general decrease in progesterone in the latter days of
the menstrual cycle appears to be due to a decrease in the progesterone
pulse amplitude. A significant correlation between LH and progesterone was
present when the data were "smoothed"; however, there was not a
significant synchrony for LH and progesterone pulses for most of the
subjects when the initial data were analyzed by objective criteria.
Progesterone secretion in the luteal phase is quite complex and leads to
highly variable serum levels of progesterone when samples are obtained at
random from normal women. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | male contraception | en_US |
dc.subject | andrology | en_US |
dc.subject | gonadotropins | en_US |
dc.subject | 5-alpha reductase inhibitors | en_US |
dc.subject | spermatogenesis | en_US |
dc.subject | testosterone | en_US |
dc.subject | colchicine | en_US |
dc.subject | klinefelter's syndrome | en_US |
dc.subject | reifenstein's syndrome | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Estrogens, blood | en_US |
dc.subject.mesh | Luteal Phase | en_US |
dc.subject.mesh | Ovarian Follicle, anatomy & histology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.subject.mesh | Progesterone, secretion | en_US |
dc.subject.mesh | Research Support, U.S. Gov't, Non-P.H.S. | en_US |
dc.subject.mesh | Luteinizing Hormone, secretion | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Corpus Luteum, physiology | en_US |
dc.subject.mesh | Research Support, U.S. Gov't, P.H.S. | en_US |
dc.title | The corpus luteum: determinants of progesterone secretion in the normal menstrual cycle | en_US |
dc.type | Article | en_US |