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dc.contributor.authorCohen, Nancy L.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorSoules, Michael R.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.date.accessioned2008-10-17T20:43:39Z
dc.date.available2008-10-17T20:43:39Z
dc.date.issued1988-05en_US
dc.identifier.citationObstet Gynecol. 1988 May;71(5):659-66en_US
dc.identifier.urihttp://hdl.handle.net/1773/4477
dc.description.abstractFourteen normal volunteers were studied during one menstrual cycle. Follicular development, the luteinizing hormone (LH) surge, and the relationship between LH and progesterone secretion in the luteal phase were studied to determine the factors that control corpus luteum function. Follicular development was assessed by measuring follicle size and daily estradiol (E2) levels; the LH surge was quantified by determining the area under the curve. Although there was a significant positive correlation between mean follicle diameter and E2, these same parameters did not correlate with postovulatory progesterone secretion; nor did the LH surge correlate with progesterone secretion. A decrease in LH pulse frequency occurred in moving from the follicular to the luteal phase. There was a trend toward an increase in the late luteal LH pulse frequency compared with the midluteal phase, but this was not significant. Progesterone was secreted in an intermittent (pulsatile) fashion in the midluteal and late luteal phases. The general decrease in progesterone in the latter days of the menstrual cycle appears to be due to a decrease in the progesterone pulse amplitude. A significant correlation between LH and progesterone was present when the data were "smoothed"; however, there was not a significant synchrony for LH and progesterone pulses for most of the subjects when the initial data were analyzed by objective criteria. Progesterone secretion in the luteal phase is quite complex and leads to highly variable serum levels of progesterone when samples are obtained at random from normal women.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectmale contraceptionen_US
dc.subjectandrologyen_US
dc.subjectgonadotropinsen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjectspermatogenesisen_US
dc.subjecttestosteroneen_US
dc.subjectcolchicineen_US
dc.subjectklinefelter's syndromeen_US
dc.subjectreifenstein's syndromeen_US
dc.subject.meshFemaleen_US
dc.subject.meshEstrogens, blooden_US
dc.subject.meshLuteal Phaseen_US
dc.subject.meshOvarian Follicle, anatomy & histologyen_US
dc.subject.meshHumansen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshProgesterone, secretionen_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.subject.meshLuteinizing Hormone, secretionen_US
dc.subject.meshAdulten_US
dc.subject.meshCorpus Luteum, physiologyen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.titleThe corpus luteum: determinants of progesterone secretion in the normal menstrual cycleen_US
dc.typeArticleen_US


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