Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus

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Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus

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dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Cheung, Clement C. en_US
dc.contributor.author Clifton, Donald K. en_US
dc.date.accessioned 2008-10-17T20:43:42Z
dc.date.available 2008-10-17T20:43:42Z
dc.date.issued 1997-10 en_US
dc.identifier.citation Endocrinology. 1997 Oct;138(10):4489-92 en_US
dc.identifier.uri http://hdl.handle.net/1773/4479
dc.description.abstract Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic nuclei suggests that multiple neuronal subtypes are targets for leptin's action. Products of the proopiomelanocortin (POMC) gene are known to affect feeding behavior, and POMC neurons share a similar distribution with leptin receptor mRNA in the arcuate nucleus. We used double label in situ hybridization and computerized image analysis to test the hypothesis that POMC neurons coexpress the leptin receptor. Quantitative analysis confirmed that POMC neurons in the hypothalamus express leptin receptor mRNA. Based on this observation, we infer that POMC neurons and the products of the POMC gene may be part of the signaling pathway mediating leptin's action on feeding and perhaps other physiological functions. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject POMC en_US
dc.subject in situ hybridization en_US
dc.subject hypothalamus en_US
dc.subject leptin receptor en_US
dc.subject.mesh Pro-Opiomelanocortin, analysis, genetics, physiology en_US
dc.subject.mesh Neurons, chemistry, drug effects, ultrastructure en_US
dc.subject.mesh RNA, Messenger, analysis, genetics, metabolism en_US
dc.subject.mesh Rats, Sprague-Dawley en_US
dc.subject.mesh Proteins, pharmacology, physiology en_US
dc.subject.mesh Carrier Proteins, analysis, genetics en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Hypothalamus, cytology, drug effects en_US
dc.subject.mesh Signal Transduction, physiology en_US
dc.subject.mesh Receptors, Cell Surface en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Eating, physiology en_US
dc.subject.mesh Rats en_US
dc.subject.mesh In Situ Hybridization en_US
dc.subject.mesh Leptin en_US
dc.subject.mesh Image Processing, Computer-Assisted en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Female en_US
dc.subject.mesh Gene Expression Regulation en_US
dc.title Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus en_US
dc.type Article en_US


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