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dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorCheung, Clement C.en_US
dc.contributor.authorClifton, Donald K.en_US
dc.date.accessioned2008-10-17T20:43:42Z
dc.date.available2008-10-17T20:43:42Z
dc.date.issued1997-10en_US
dc.identifier.citationEndocrinology. 1997 Oct;138(10):4489-92en_US
dc.identifier.urihttp://hdl.handle.net/1773/4479
dc.description.abstractLeptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic nuclei suggests that multiple neuronal subtypes are targets for leptin's action. Products of the proopiomelanocortin (POMC) gene are known to affect feeding behavior, and POMC neurons share a similar distribution with leptin receptor mRNA in the arcuate nucleus. We used double label in situ hybridization and computerized image analysis to test the hypothesis that POMC neurons coexpress the leptin receptor. Quantitative analysis confirmed that POMC neurons in the hypothalamus express leptin receptor mRNA. Based on this observation, we infer that POMC neurons and the products of the POMC gene may be part of the signaling pathway mediating leptin's action on feeding and perhaps other physiological functions.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectPOMCen_US
dc.subjectin situ hybridizationen_US
dc.subjecthypothalamusen_US
dc.subjectleptin receptoren_US
dc.subject.meshPro-Opiomelanocortin, analysis, genetics, physiologyen_US
dc.subject.meshNeurons, chemistry, drug effects, ultrastructureen_US
dc.subject.meshRNA, Messenger, analysis, genetics, metabolismen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshProteins, pharmacology, physiologyen_US
dc.subject.meshCarrier Proteins, analysis, geneticsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHypothalamus, cytology, drug effectsen_US
dc.subject.meshSignal Transduction, physiologyen_US
dc.subject.meshReceptors, Cell Surfaceen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshEating, physiologyen_US
dc.subject.meshRatsen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshLeptinen_US
dc.subject.meshImage Processing, Computer-Assisteden_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulationen_US
dc.titleProopiomelanocortin neurons are direct targets for leptin in the hypothalamusen_US
dc.typeArticleen_US


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