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dc.contributor.authorRen, Hongpingen_US
dc.contributor.authorClifton, Donald K.en_US
dc.contributor.authorWeigle, David S.en_US
dc.contributor.authorSteiner, Robert A.en_US
dc.contributor.authorKuijper, Joseph L.en_US
dc.contributor.authorKabigting, Emilia B.en_US
dc.contributor.authorBarash, Ilona A.en_US
dc.contributor.authorCheung, Clement C.en_US
dc.date.accessioned2008-10-17T20:43:51Z
dc.date.available2008-10-17T20:43:51Z
dc.date.issued1996-07en_US
dc.identifier.citationEndocrinology. 1996 Jul;137(7):3144-7en_US
dc.identifier.urihttp://hdl.handle.net/1773/4488
dc.description.abstractLeptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin signals metabolic information to the reproductive system by examining its effects on the reproductive system of ob/ob mice, which have a congenital deficiency in leptin and are infertile. We treated pair-fed males and females with leptin (50 microg twice daily, ip) or vehicle (n=10/group) for 14 days, after which the animals were bled and killed. Leptin-treated females had significantly elevated serum levels of LH, increased ovarian and uterine weights, and stimulated aspects of ovarian and uterine histology compared to controls. Leptin-treated males had significantly elevated serum levels of FSH, increased testicular and seminal vesicle weights, greater seminal vesicle epithelial cell height, and elevated sperm counts compared to controls. These results demonstrate that leptin stimulates the reproductive endocrine system in both sexes of ob/ob mice and suggest that leptin may serve as a permissive signal to the reproductive system of normal animals.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectleptinen_US
dc.subjectmetabolismen_US
dc.subjectleptin receptoren_US
dc.subject.meshTestis, anatomy & histology, drug effects, physiologyen_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshLeptinen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Obeseen_US
dc.subject.meshMaleen_US
dc.subject.meshSeminal Vesicles, anatomy & histology, drug effects, physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshOvarian Follicle, drug effects, physiologyen_US
dc.subject.meshObesity, genetics, physiopathologyen_US
dc.subject.meshOligospermiaen_US
dc.subject.meshProtein Biosynthesisen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshHumansen_US
dc.subject.meshFemaleen_US
dc.subject.meshOrgan Size, drug effectsen_US
dc.subject.meshUterus, anatomy & histology, drug effects, physiologyen_US
dc.subject.meshSaccharomyces cerevisiaeen_US
dc.subject.meshRecombinant Proteins, biosynthesis, pharmacologyen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshProteins, pharmacologyen_US
dc.subject.meshOvary, anatomy & histology, drug effects, physiologyen_US
dc.titleLeptin is a metabolic signal to the reproductive systemen_US
dc.typeArticleen_US


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