Leptin is a metabolic signal to the reproductive system

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Leptin is a metabolic signal to the reproductive system

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dc.contributor.author Ren, Hongping en_US
dc.contributor.author Clifton, Donald K. en_US
dc.contributor.author Weigle, David S. en_US
dc.contributor.author Steiner, Robert A. en_US
dc.contributor.author Kuijper, Joseph L. en_US
dc.contributor.author Kabigting, Emilia B. en_US
dc.contributor.author Barash, Ilona A. en_US
dc.contributor.author Cheung, Clement C. en_US
dc.date.accessioned 2008-10-17T20:43:51Z
dc.date.available 2008-10-17T20:43:51Z
dc.date.issued 1996-07 en_US
dc.identifier.citation Endocrinology. 1996 Jul;137(7):3144-7 en_US
dc.identifier.uri http://hdl.handle.net/1773/4488
dc.description.abstract Leptin, a newly-discovered hormonal product of the obese (ob) gene, is expressed by adipocytes and thought to play a role in the regulation of food intake and metabolism. We tested the hypothesis that leptin signals metabolic information to the reproductive system by examining its effects on the reproductive system of ob/ob mice, which have a congenital deficiency in leptin and are infertile. We treated pair-fed males and females with leptin (50 microg twice daily, ip) or vehicle (n=10/group) for 14 days, after which the animals were bled and killed. Leptin-treated females had significantly elevated serum levels of LH, increased ovarian and uterine weights, and stimulated aspects of ovarian and uterine histology compared to controls. Leptin-treated males had significantly elevated serum levels of FSH, increased testicular and seminal vesicle weights, greater seminal vesicle epithelial cell height, and elevated sperm counts compared to controls. These results demonstrate that leptin stimulates the reproductive endocrine system in both sexes of ob/ob mice and suggest that leptin may serve as a permissive signal to the reproductive system of normal animals. en_US
dc.language.iso en_US en_US
dc.publisher Endocrine Society en_US
dc.subject leptin en_US
dc.subject metabolism en_US
dc.subject leptin receptor en_US
dc.subject.mesh Testis, anatomy & histology, drug effects, physiology en_US
dc.subject.mesh Luteinizing Hormone, blood en_US
dc.subject.mesh Research Support, Non-U.S. Gov't en_US
dc.subject.mesh Research Support, U.S. Gov't, P.H.S. en_US
dc.subject.mesh Leptin en_US
dc.subject.mesh Mice en_US
dc.subject.mesh Mice, Obese en_US
dc.subject.mesh Male en_US
dc.subject.mesh Seminal Vesicles, anatomy & histology, drug effects, physiology en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Ovarian Follicle, drug effects, physiology en_US
dc.subject.mesh Obesity, genetics, physiopathology en_US
dc.subject.mesh Oligospermia en_US
dc.subject.mesh Protein Biosynthesis en_US
dc.subject.mesh Mice, Inbred C57BL en_US
dc.subject.mesh Follicle Stimulating Hormone, blood en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Female en_US
dc.subject.mesh Organ Size, drug effects en_US
dc.subject.mesh Uterus, anatomy & histology, drug effects, physiology en_US
dc.subject.mesh Saccharomyces cerevisiae en_US
dc.subject.mesh Recombinant Proteins, biosynthesis, pharmacology en_US
dc.subject.mesh Analysis of Variance en_US
dc.subject.mesh Proteins, pharmacology en_US
dc.subject.mesh Ovary, anatomy & histology, drug effects, physiology en_US
dc.title Leptin is a metabolic signal to the reproductive system en_US
dc.type Article en_US


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