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dc.contributor.authorWoodruff, Teresa K.en_US
dc.contributor.authorSoules, Michael R.en_US
dc.contributor.authorHansen, Karl R.en_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorSluss, Patrick M.en_US
dc.contributor.authorKlein, Nancy A.en_US
dc.contributor.authorHoumard, Brenda S.en_US
dc.date.accessioned2008-10-17T20:43:52Z
dc.date.available2008-10-17T20:43:52Z
dc.date.issued2004-06en_US
dc.identifier.citationJ Clin Endocrinol Metab. 2004 Jun;89(6):2977-81en_US
dc.identifier.urihttp://hdl.handle.net/1773/4489
dc.description.abstractPrevious studies have reported that the monotropic rise in FSH in older women is associated with decreased inhibin B and/or A levels and increased levels of activin A. Whereas most investigators have found decreased follicular-phase inhibin B, the roles of inhibin A and activin A as modulators of the FSH rise are unclear. The objectives of this study were to determine whether deficiencies in circulating levels of inhibin A, inhibin B, and/or activin A exist during the intercycle interval in ovulatory older (age, 40-45 yr; n = 16), compared with younger women (age, 20-25 yr; n = 13). Blood samples were obtained daily throughout one menstrual cycle and the follicular phase of the subsequent cycle and were analyzed for LH, FSH, estradiol, inhibin A and B, and activin A. Despite significant FSH elevation, no deficiencies in inhibin A, activin A, or estradiol were detected in older subjects. In fact, inhibin A was significantly higher in older participants during the intercycle phase (P = 0.01), whereas inhibin B was significantly lower. Thus, the monotropic rise in FSH does not appear to result from changes in inhibin A or activin A, supporting the concept that inhibin B plays a critical role in mediating the FSH rise in older women.en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectandrologyen_US
dc.subjectmale contraceptionen_US
dc.subject.meshHumansen_US
dc.subject.meshFollicular Phase, metabolismen_US
dc.subject.meshInhibins, blooden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshInhibin-beta Subunits, blooden_US
dc.subject.meshBiological Markersen_US
dc.subject.meshProgesterone, blooden_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshActivins, blooden_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshEstradiol, blooden_US
dc.subject.meshAdulten_US
dc.subject.meshAging, metabolismen_US
dc.titleAge-related analysis of inhibin A, inhibin B, and activin a relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory womenen_US
dc.typeArticleen_US


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