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dc.contributor.authorBailey, Roberten_US
dc.contributor.authorGriswold, Michael D.en_US
dc.date.accessioned2008-10-17T20:44:04Z
dc.date.available2008-10-17T20:44:04Z
dc.date.issued1999-05-25en_US
dc.identifier.citationMol Cell Endocrinol. 1999 May 25;151(1-2):17-23en_US
dc.identifier.urihttp://hdl.handle.net/1773/4500
dc.description.abstractClusterin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic of the expression of clusterin is that it is induced as a result of cellular injury, death, or pathology. Despite the efforts of many laboratories working in diverse biological systems, the function of clusterin remains unknown. Recent studies have revealed a 'heat-shock element' in the promoter of the gene that may account for the inducible nature of the clusterin gene. Overall, the evidence suggests that function of clusterin is to protect surviving cells after damage. This protection may result from a detergent-like action of the protein.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectcellular injuryen_US
dc.subjectmale reproductive systemen_US
dc.subjectclusterinen_US
dc.subject.meshMolecular Chaperonesen_US
dc.subject.meshGlycoproteins, physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Survival, physiologyen_US
dc.subject.meshGenitalia, Male, pathology, physiologyen_US
dc.subject.meshClusterinen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.titleClusterin in the male reproductive system: localization and possible functionen_US
dc.typeArticleen_US


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