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Clusterin in the male reproductive system: localization and possible function

Show simple item record Bailey, Robert en_US Griswold, Michael D. en_US 2008-10-17T20:44:04Z 2008-10-17T20:44:04Z 1999-05-25 en_US
dc.identifier.citation Mol Cell Endocrinol. 1999 May 25;151(1-2):17-23 en_US
dc.description.abstract Clusterin is a glycoprotein that was initially isolated from the male reproductive system. Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. One characteristic of the expression of clusterin is that it is induced as a result of cellular injury, death, or pathology. Despite the efforts of many laboratories working in diverse biological systems, the function of clusterin remains unknown. Recent studies have revealed a 'heat-shock element' in the promoter of the gene that may account for the inducible nature of the clusterin gene. Overall, the evidence suggests that function of clusterin is to protect surviving cells after damage. This protection may result from a detergent-like action of the protein. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject cellular injury en_US
dc.subject male reproductive system en_US
dc.subject clusterin en_US
dc.subject.mesh Molecular Chaperones en_US
dc.subject.mesh Glycoproteins, physiology en_US
dc.subject.mesh Animals en_US
dc.subject.mesh Cell Survival, physiology en_US
dc.subject.mesh Genitalia, Male, pathology, physiology en_US
dc.subject.mesh Clusterin en_US
dc.subject.mesh Humans en_US
dc.subject.mesh Male en_US
dc.title Clusterin in the male reproductive system: localization and possible function en_US
dc.type Article en_US

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