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dc.contributor.authorSnyder, Peter J.en_US
dc.contributor.authorBremner, William J.en_US
dc.contributor.authorMcLachlan, Robert I.en_US
dc.contributor.authorFinkel, David M.en_US
dc.date.accessioned2008-10-17T20:44:06Z
dc.date.available2008-10-17T20:44:06Z
dc.date.issued1990-05en_US
dc.identifier.citationJ Clin Endocrinol Metab. 1990 May;70(5):1414-9en_US
dc.identifier.urihttp://hdl.handle.net/1773/4502
dc.description.abstractWe measured by RIA the inhibin concentrations in the sera of 20 men with hypogonadotropic hypogonadism before and during treatment with gonadotropins in order to determine the role of gonadotropins in the control of inhibin secretion and the utility of the serum inhibin concentration in assessing the spermatogenic response to gonadotropin treatment in these patients. Before treatment the mean serum inhibin concentration in the 20 hypogonadotropic men as a group (391 +/- 49 U/L) was significantly lower (P less than 0.001) than that in 27 normal men (741 +/- 52 U/L). In the 7 men whose hypogonadism was of postpubertal onset, the mean serum inhibin concentration (559 +/- 69 U/L) was not significantly lower than that in normal men. In the 13 men whose hypogonadism was of prepubertal onset, the serum inhibin level was significantly lower [381 +/- 74 U/L (P less than 0.01) in the 7 without a history of cryptorchidism and 207 +/- 46 U/L (P less than 0.01) in the 6 with a history of cryptorchidism]. All 20 patients were azoospermic or severely oligospermic and had distinctly subnormal serum testosterone concentrations, even those whose serum inhibin values were normal. In the 7 patients with postpubertal hypogonadism, treatment with hCG alone for 6 months increased the serum testosterone concentration and maximum sperm count to normal, even though the previously normal inhibin concentration was not increased further. In the 13 patients with prepubertal hypogonadism, treatment with hCG alone increased the serum inhibin concentration, and combined treatment with hCG and human menopausal gonadotropin (hMG) increased inhibin further, to well within the normal range (742 +/- 143 U/L) in the patients without a history of cryptorchidism and to just within the normal range (487 +/- 96 U/L) in those with such a history. In the 7 patients with prepubertal hypogonadism but no history of cryptorchidism, treatment with hCG and hMG increased the maximum sperm count to normal in 5. In the 6 patients with prepubertal hypogonadism who did have a history of cryptorchidism, hCG and hMG treatment produced a normal sperm count in only 1. Of 12 patients whose serum inhibin level was more than 300 U/L before treatment, 11 developed a normal maximum sperm count in response to treatment, but of 8 patients whose inhibin concentration was less than 300 U/L before treatment, only 2 developed a normal sperm count in response to treatment (P less than 0.01).(ABSTRACT TRUNCATED AT 400 WORDS)en_US
dc.language.isoen_USen_US
dc.publisherEndocrine Societyen_US
dc.subjectmale contraceptionen_US
dc.subjectandrologyen_US
dc.subject5-alpha reductase inhibitorsen_US
dc.subjecttestosteroneen_US
dc.subjectgonadotropinsen_US
dc.subjectcolchicineen_US
dc.subjectklinefelter's syndromeen_US
dc.subjectreifenstein's syndromeen_US
dc.subjectspermatogenesisen_US
dc.subject.meshGonadotropins, Pituitary, administration & dosage, blood, deficiency, physiologyen_US
dc.subject.meshFollicle Stimulating Hormone, blood, physiologyen_US
dc.subject.meshHypogonadism, blood, drug therapyen_US
dc.subject.meshLuteinizing Hormone, blood, physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshOligospermia, blood, drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMenotropins, administration & dosageen_US
dc.subject.meshResearch Support, U.S. Gov't, P.H.S.en_US
dc.subject.meshInhibins, blood, physiologyen_US
dc.subject.meshChorionic Gonadotropin, administration & dosageen_US
dc.subject.meshEunuchism, blood, drug therapyen_US
dc.subject.meshAdulten_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshResearch Support, U.S. Gov't, Non-P.H.S.en_US
dc.titleSerum inhibin concentrations before and during gonadotropin treatment in men with hypogonadotropic hypogonadism: physiological and clinical implicationsen_US
dc.typeArticleen_US


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