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dc.contributor.authorBremner, William J.en_US
dc.contributor.authorYang, Pei-Juanen_US
dc.contributor.authorAmory, John K.en_US
dc.contributor.authorGao, Er-Shengen_US
dc.contributor.authorYang, Jieen_US
dc.contributor.authorZheng, E-Xiangen_US
dc.contributor.authorGui, You-Lunen_US
dc.contributor.authorHe, Chang-Haien_US
dc.date.accessioned2008-10-17T20:44:07Z
dc.date.available2008-10-17T20:44:07Z
dc.date.issued2004-09en_US
dc.identifier.citationJ Androl. 2004 Sep-Oct;25(5):720-7en_US
dc.identifier.urihttp://hdl.handle.net/1773/4503
dc.description.abstractMonthly injections of testosterone undecanoate (TU) act as a male contraceptive by reversibly suppressing spermatogenesis to azoospermia or severe oligoazoospermia in 95% of Chinese men. In 5% of Chinese men, however, monthly TU administered alone fails to suppress spermatogenesis into contraceptive ranges, or sperm "rebound," leading to occurrences of pregnancy during treatment. Since combinations of progestins and androgens are associated with greater degrees of sperm suppression in white men, we hypothesized that the combination of TU and the progestin levonorgestrel (LNG) would result in improved spermatogenic suppression in Chinese men. Sixty-two healthy Chinese men were randomly assigned to one of the following 3 regimens: group I (n = 21) received 4 LNG rods (75 mg each), which were followed 4 weeks later by 500 mg of TU by intra-muscular (IM) injection every 8 weeks for 24 weeks; group II (n = 20) received 4 LNG implants, which were followed 4 weeks later by 1000 mg of TU by IM injection every 8 weeks for 24 weeks; and group III (n = 21) received TU 1000 mg by IM injection every 8 weeks for 24 weeks. Sperm counts, serum testosterone (T), luteinizing hormone, follicle-stimulating hormone, and LNG were measured every 2 weeks before, during, and after treatment. During treatment, group II demonstrated a trend toward a greater attainment of azoospermia than groups I and III (90% vs 62% [group I] vs 67% [group III]; P =.09). Attainments of either azoospermia or oligozoospermia (sperm density, <3 x 10(6)/mL) were 95%, 100%, and 86% for groups I, II, and III, respectively (P >.05 for comparisons between groups). Spermatogenesis in all subjects returned to the normal range after the implants were removed. No serious adverse events and no significant changes in serum chemistry occurred during the study. These results demonstrate that the combination of IM injections of high-dose TU every 2 months and LNG implants is associated with marked suppression of spermatogenesis in Chinese men. The combination of high-dose TU every 2 months and LNG implants is a promising candidate for future large-scale efficacy studies of hormonal male contraception in Chinese men.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Andrologyen_US
dc.subjectandrogensen_US
dc.subjectcontraceptiveen_US
dc.subjectprogestinsen_US
dc.subjectfamily planningen_US
dc.subject.meshHumansen_US
dc.subject.meshFollicle Stimulating Hormone, blooden_US
dc.subject.meshLevonorgestrel, administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshInjections, Intramuscularen_US
dc.subject.meshAbsorbable Implantsen_US
dc.subject.meshSpermatozoa, drug effectsen_US
dc.subject.meshResearch Support, Non-U.S. Gov'ten_US
dc.subject.meshSperm Counten_US
dc.subject.meshLuteinizing Hormone, blooden_US
dc.subject.meshAntispermatogenic Agents, administration & dosageen_US
dc.subject.meshContraception, methodsen_US
dc.subject.meshAdulten_US
dc.subject.meshSpermatogenesis, drug effectsen_US
dc.subject.meshTestosterone, administration & dosage, analogs & derivatives, blooden_US
dc.titleMale hormonal contraception: suppression of spermatogenesis by injectable testosterone undecanoate alone or with levonorgestrel implants in chinese menen_US
dc.typeArticleen_US


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