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dc.contributor.advisorDeForest, Cole A
dc.contributor.authorOrr, Luke Edward
dc.date.accessioned2022-07-14T22:07:16Z
dc.date.submitted2022
dc.identifier.otherOrr_washington_0250O_24453.pdf
dc.identifier.urihttp://hdl.handle.net/1773/48862
dc.descriptionThesis (Master's)--University of Washington, 2022
dc.description.abstractThe complex vascular networks that exist throughout living organisms are necessary to sustain life, transporting nutrients and oxygen to and waste products from tissues in the blood. Though recent advances in biofabrication have made substantial strides, success in replicating vascular complexities at native resolution and scale in anatomically defined patterns remains limited. In this thesis, I demonstrate that multiphoton sculpting of hyper-photodegradable hydrogels through a tiled image stack-guided methodology rapidly affords perfusable microvascular networks of unprecedented size and complexity. These results have major implications for studying vasculature biology in vitro and in the creation of functional engineered tissues for in vivo transplantation.
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.relation.haspartBrainPassthrough.mp4; video; Video showcasing the microvasculature structure patterned within a RuOrange hydrogel. .
dc.rightsnone
dc.subjectHydrogel
dc.subjectMicrovasculature
dc.subjectMultiphoton Degradation
dc.subjectMultiphoton Patterning
dc.subjectTissue Engineering
dc.subjectChemical engineering
dc.subjectBioengineering
dc.subject.otherChemical engineering
dc.titleImage-Guided Microvasculature Generation in Photodegradable Hydrogels
dc.typeThesis
dc.embargo.termsEmbargo for 1 year -- then make Open Access
dc.embargo.lift2024-07-03T22:07:16Z


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