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Browsing Dissertations and Theses by Author "Gelb, Michael H"
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Capture and Identification of a Novel Protein in the Necrotic Cell Death Pathway and Toward Discovery of Inhibitors of Human Group III Secreted Phospholipase A2 and Lessons Learned from In Vivo Mouse Studies of Secreted Phospholipase A2 Clearance from Extra-Cellular Medium by the M-type Receptor
Ewing, Heather NoelaniChapter I. Capture and Identification of a Novel Protein in the Necrotic Cell Death Pathway The serine hydrolase inhibitors Pyrrophenone and KT195 were found to inhibit cell death induced by A23187 and H2O2 in mouse lung ... -
Development and Application of Novel Methodologies for the Characterization of Phospholipase A2 Activity: Targeted Lipidomic Profiling and Interfacial Binding Analysis
Bollinger, James Gerard (2013-07-23)Phospholipases A2 are a family of enzymes that hydrolyze membrane glycerophospholipids to yield free fatty acids and lysophospholipids. Both products serve as precursors for an array of lipid mediators that play known roles ... -
Development of Mass Spectrometry-Based Assays for Newborn Screening: Novel Approaches to Lysosomal Acid Lipase and the Mucopolysaccharidoses
Masi, SophiaNewborn screening has been an important public health tool for over fifty years. As technology improves, new testing has developed for rare diseases including lysosomal storage disorders (LSDs) in parallel with novel ... -
Development of Newborn Screening Methods for Mucopolysaccharidosis III type A and type B in Dried Blood Spot using Tandem Mass Spectrometry
Yi, FanChapter I. Development of Newborn Screening Method for Mucopolysaccharidosis III Type A in Dried Blood Spot using Tandem Mass Spectrometry Mucopolysaccharidosis III type A (MPS III A) is an autosomal recessive inherited ...