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Browsing Dissertations and Theses by Subject "Immunology"
Now showing items 1-20 of 220
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33D1+ Dendritic Cells in Tolerance and Immunity
CD4+ Foxp3+ regulatory T cells (Tr cells) are potent anti-inflammatory cells which naturally suppress autoimmune disease by tempering immune responses to self- and foreign-antigens. Given their integral role in the ... -
A genome-scale gain-of-function screening platform nominates genetic modulators for CAR T cell therapy enhancement
Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer care through genetic reprogramming, and next-generation cell engineering aims to encode increasingly complex genetic programs to further modulate T ... -
A lentiviral vector deep mutational scanning system for studying virus evolution and escape from neutralization by antibodies and polyclonal serum
Viral entry proteins are critical for viral replication of enveloped viruses. These proteins allow viruses to bind receptors on cells and accomplish membrane fusion. Since viral entry proteins are located on the viral ... -
A novel translational bioinformatics pipeline to improve precision medicine research
Diverse Mouse models can serve as precursors to precision medicine in clinical practice (Li & Auwerx, 2020) but requires the integration, analysis, and cross-species interpretation across multi-omics data sets. We present ... -
Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype of B-ALL often associated with genetic variants that alter cytokine receptor signaling, including mutations in the interleukin-7 ... -
Activated PI3Kδ signaling in humoral immunity
p110δ, the catalytic subunit of phosphoinositide 3 kinase delta (PI3Kδ), is mainly expressed in immune cells and plays an important role in the development, activation, and differentiation of B cells. Gain-of-function ... -
Activation and regulation of MAIT cells within mucosal tissues
Mucosal-associated invariant T (MAIT) cells are a class of unconventional T cells that are defined by a limited T cell receptor (TCR) repertoire that recognize microbial riboflavin-derivative antigens presented by the major ... -
ADAR1 mutation causes ZBP1-dependent immunopathology
The RNA editing enzyme ADAR1 is essential for suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous ... -
ADAR1 Regulation of Innate RNA Sensing in Immune Disease
Detection of nucleic acids and production of type I interferons (IFNs) are principal elements of antiviral defense, but can cause autoimmune disease if dysregulated. Loss of function mutations in the human ADAR gene cause ... -
Alternative splicing takes control of cytokine signaling
Immune responses must be tightly controlled for dose, location, strength and duration using genetic, epigenetic or biochemical regulation. Among these, the generation of alternatively-spliced transcripts is an efficient ... -
An innate-like role of memory T cells in HSV-2 immunity
Mucosal infections pose a significant global health burden and remain a top cause of mortality worldwide. Herpes Simplex Virus type-2 (HSV-2) infection is one of the most prevalent sexually transmitted infections, yet no ... -
Analysis of epitope-specific HIV CD8+ T cell responses elicited during early HIV-1 infection and their association with viral control
(2013-04-17)The enormity of global human immunodeficiency virus type 1 (HIV)/acquired immunodeficiency syndrome (AIDS) pandemic underscores the urgency to develop a safe, effective and accessible prophylactic AIDS vaccine. Multiple ... -
Analysis of types of Tumor-Infiltrating Immune Cells in Oral Squamous Cell Carcinoma (OSCC) and their associations with survival of OSCC patients.
Background: The 5-year survival associated with oral cancer (OSCC) is relatively low. Recent investigations have implicated the presence of tumor infiltrating lymphocytes (TILs) as independent prognostic markers in several ... -
Ancient and ongoing viral adaptation to antagonize primate SAMHD1
Restriction factors are components of the innate immune defense against viral pathogens. They inhibit viral replication by operating as molecular barriers to steps of the viral life cycle, and viruses have evolved mechanisms ... -
Antigen Perception in T Cells
The immune system’s threat detection hinges on T cells’ ability to perceive differences in the quality and quantity of peptide-major histocompatibility complex (pMHC) antigens. Our T cells are tolerant to the vast majority ... -
B cell intrinsic gain of function mutations in B cell development and function: a story of activated CARD11 and PI3K
Gain of function mutations in key signaling molecules downstream of the B cell receptor have been linked to both malignancy and monogeneic primary immunodeficiencies. This study is focused on characterizing the impact of ... -
B cells promote inflammatory T cell responses during the initiation of central nervous system autoimmune disease
(2013-07-25)Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) mediated by autoreactive T cells specific for myelin proteins. A recent development in MS treatment is the discovery that ... -
B cells, not dendritic cells, prime the dominant CD4+ Tfh response to Plasmodium infection
CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood- stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression. We studied antigen-specific ... -
BCAP functions as a dynamic regulator of hematopoiesis and myeloid cell development
Hematopoiesis governs the production of mature cells of the lymphoid, myeloid and erythroid lineages. This process occurs in the bone marrow of adult mammals, and generates these lineages throughout life. Furthermore, ... -
BCAP promotes lupus-like disease and TLR-induced IFNα production in plasmacytoid dendritic cells
Systemic lupus erythematosus (SLE) severity correlates with elevated serum levels of type I interferons (IFN), cytokines produced in large quantities by plasmacytoid dendritic cells (pDC) in response to engagement of TLR7 ...