Browsing Dissertations and Theses by Author "Moon, Randall T"
Now showing items 1-5 of 5
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Characterization of novel, context-dependent modulators of WNT signaling in cancer
Anastas, Jamie Nicole (2013-07-23)WNTs comprise a family of secreted proteins that play critical roles in both embryogenesis and in the etiology of human diseases such as cancer. Even after more than three decades of research, our understanding of the ... -
Pharmacologic regulation of Wnt/β-Catenin Signaling in Stem and Progenitor Cells
Robin, Nicholas (2014-04-30)The Wnt/Ã -Catenin signaling pathway is a key regulator of proliferation, differentiation, and programmed cell death in stem and progenitor cells. Misregulated or aberrant signaling events in the pathway contributes to the ... -
Resolving mechanisms of apoptosis in response to WNT3A in Melanoma
Conrad, William (2013-04-17)Wnt/β-catenin and ERK/MAPK signaling regulate the balance of differentiation and proliferation in melanoma. Aberrant activation of ERK/MAPK signaling results from the BRAFV600E or NRASQ61X mutations in greater than 70% of ... -
Wnt/β-catenin Signaling Regulates Regeneration in Diverse Tissues of the Zebrafish
Strand, NicholasThe ability to regenerate tissue after injury is limited by species, tissue type, and age of the organism. Understanding the mechanisms of endogenous regeneration provides greater insight into this remarkable biological ... -
WTX is a novel regulator of ubiquitination in the Wnt/beta-catenin and KEAP1/NRF2 pathways
Camp, Nathan (2012-08-10)Ubiquitination of proteins and subsequent proteosome-mediated degradation is one mechanism cells use to regulate protein steady-state levels. This essential process permits cells to rapidly respond to extracellular cues ...