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Factors associated with sexual risk of HIV transmission among HIV-positive Latino men who have sex with men on the U.S.-Mexico border
We present results from a cross-sectional, clinic-based survey of border-region Latino men who have sex with men (MSM) who are living with HIV. Among the 66 participants who reported potentially serodiscordant anal or vaginal intercourse, we examined levels of psychological distress and substance use and the association of ...
Genetic and environmental associations with disease risk and drug response in Alaska Native people, and a responsive justice approach to reconciling statistical and ethical research demands.
Genetic research with diverse and underserved communities is important for expanding the benefits of genetic discoveries and their application to personalized medicine. In partnership with Alaska Native communities, we identified and characterized novel and known variation in CYP2C9, VKORC1, CYP4F2, CYP4F11, and GGCX, 5 genes ...
Genetic testing for Autism Spectrum Disorder (ASD): evaluating the challenges of genomic translation
Genetic testing for ASD is a new, complex and evolving aspect of healthcare, occurring in the setting of substantial challenges to the diagnosis and treatment of this group of conditions (Jeste & Geschwind, 2014). To date there has been little focused research examining what families experience through the genetic testing ...
Relationship Dynamics as Inconsistent Mediators of Traumatic Stress and Condomless Sex Among Jail-detained Women
Incarcerated women, especially women in jail, are at high risk for HIV and other sexually transmitted diseases. Research is needed to establish the key predictors of risk behavior, so that these can be targeted in interventions. Traumatic stress, substance use and intimate relationship dynamics likely influence infection and ...
Effects of Prolonged and Timing-Specific Exposure to Neighborhood Disadvantage during Childhood and Adolescence on Health and Health Inequalities in Early Adulthood
Mounting evidence that purely individual-based explanations fail to fully explain persistent disparities in morbidity and mortality has contributed to a surge in research investigating how residential contexts further shape the health of individual residents. Until recently, however, the majority of scholarship in this area ...
Adaptive designs in the time to event setting: The potential for benefit and risk
Group sequential designs (GSDs) have been the standard sequential approach to maintain scientific, ethical, and efficiency goals in any confirmatory Phase III studies. Over the past two decades, adaptive extensions to group sequential designs have been proposed to allow more flexible modification of aspects of the trial. ...
Social Support Networks and Self-Efficacy of Peruvian Women Diagnosed with Cancer: A Biocultural Analysis of Health Behavior Constructs
Objectives The primary goal of this dissertation research study was to contextualize health behavior psychological constructs such as self-efficacy and fatalism among cancer patients in Peru, identifying individual, social, cultural and structural factors that are associated with these constructs. The secondary goal was to ...
Evaluation of Physical Activity Programs Taking Place at The Pike Market Senior Center
Background: Physical activity provides many benefits for older adults, including the prevention and control of heart disease, prevention of obesity, management of diabetes, increased independence, increased socialization and decreased levels of depression. Through the physical activity classes SAIL and yoga, the Pike Market ...
Under the Bridge: Utilizing Covered Liminal Spaces for Sanctioned Homeless Encampments in the City of Seattle
The number of homeless sleeping outside in Seattle has increased significantly in the past few years, from 2,600 in 2012 to 4,500 in 2016. In response, the City has begun to spearhead the development of temporary sanctioned homeless encampments on vacant public land as an innovative alternative to an overburdened emergency ...
Effects of GeneXpert MTB/RIF Testing and GxAlert eHealth Platforms on MDR-TB Diagnosis and Linkage to Care in Sofala Province, Mozambique
Introduction: Mozambique ranks as one of the 22 highest tuberculosis (TB) burden countries in the world but has one of the lowest TB case detection rates of only 39%. To improve Multi-Drug Resistant TB (MDR-TB) case detection rates and linkage to care, we installed three GeneXpert MTB/RIF machines in Sofala Province starting ...