Presbycusis, the progressive loss of hearing that occurs with aging, is a widespread condition with serious economical and social ramifications. Mice with age-related hearing loss (AHL) are commonly used as models of ...

Sex steroid hormones modulate vocal communication in a number of species. While much is known about the impact of these hormones on the motor systems responsible for generating vocal output, less is known about the influence ...

Stress-induced release of dynorphin and subsequent activation of the kappa opioid receptor (KOR) has been hypothesized to mediate the dysphoric component of stress. Evidence suggests that this dysphoria can alternately ...

Mechanosensory hair cells in the inner ear are vulnerable to damage that can result in hearing loss and balance disorders. Exposure to excessive noise and ototoxic drugs are two of the leading causes of hair cell loss, ...

Two cannabinoid (CB) receptors, CB1 and CB2, have been identified at the molecular level. Evidence suggests that other cannabinoid and cannabinboid-like receptors remain to be identified. Using newly developed compounds, ...

When objects move, they change position over time. However, the mechanisms in human vision that could be capable of tracking these changes in position are not well understood. I constructed stimuli that combined a first-order ...

Difficult decisions often require evaluation of samples of evidence that are acquired sequentially. If samples of evidence differ in their reliability and an unlimited number of samples can be acquired sequentially, the ...

The goal of the field of neuroeconomics is to understand the neural representations of variables relevant to theories of decision-making. These variables include the expected value of a prospect and the uncertainty ...

Melanopsin is the photopigment in intrinsically photosensitive retina ganglion cells (ipRGCs). Melanopsin endows ipRGCs with a photo-response that can act independently or be summed directly with input from rods and cones, ...

Perineuronal nets are structures in the extracellular matrix that previous work implicates in either inhibiting synaptic plasticity or protecting neurons from oxidative damage. We use histological techniques to explore the ...