Browsing Neuroscience by Title
Now showing items 26-45 of 117
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Development and regeneration of neuronal circuits in the vertebrate retina
Like in other parts of the central nervous system (CNS), information processing in the retina depends upon the exquisite organization of synaptic connectivity amongst diverse neuronal cell types. Assembly of neuronal ... -
Development and regulation of synaptic divergence in the mammalian retina
During neural development, neurons must not only contact the appropriate postsynaptic partners, but also form precise stereotypic patterns of connectivity, the characteristic number and distribution of synapses onto partners. ... -
Development of a Murine Model for Hot Flashes
Hot flashes plague millions of reproductive age men and women who have natural or iatrogenic loss of sex steroid production. Many affected individuals are left without treatment options because of contraindications to ... -
Development, generation, and origin of synchronous oscillations in the brainstem respiratory network
(2006)Neurons within the intact respiratory network are synchronized on long and short time scales to generate respiratory rhythm and synchronous oscillations in spike firing during inspiration (Figure 1.1), respectively. Such ... -
Dissociable Cost and Benefit Encoding of Future Rewards by Mesolimbic Dopamine
(University of Washington Graduate School, 2011-08-01)Dopamine is a neural substrate implicated in the complex computation of weighing the costs and benefits of future actions. Midbrain dopamine neurons encode fundamental economic parameters pertaining to predicted rewards ... -
Distinct Mechanisms Underlie Regeneration of Mechanosensory Hair Cells in Zebrafish
The mechanosensory hair cells of the inner ear mediate hearing and balance. Widespread loss of these hair cells results in severe hearing and balance deficits. Humans and other mammals are unable to regrow lost hair cells, ... -
Diversity of lateral habenula neuron roles in negative valence events
The lateral habenula (LHb) integrates critical information regarding aversive stimuli that shapes decision making and behavioral responses. Three major LHb outputs innervate dorsal raphe nucleus (DRN), ventral tegmental ... -
The dynamics of category-specific perception in ventral temporal cortex
My thesis investigates the relationship between the ventral temporal cortex and perception of different categories of visual stimuli, in humans. Under the guidance of my scientific and clinical mentors, we performed a set ... -
The dysfunction and therapeutic potential of the endocannabinoid system in Huntington's disease
Huntington's Disease is an autosomal dominant progressive neurodegenerative disease, which features profound disturbance of the basal ganglia, and in particular medium spiny neurons of the caudate/putamen. Of the many ... -
Effects of deleterious opsin gene variants on cone photoreceptor structure, function, and viability
(2013-07-25)Specific L/M-opsin interchange variants have recently been linked to a variety of eye disorders that include diminished ERGs, color blindness, and pathologically high myopia. One disease-causing variant, designated LVAVA ... -
Elucidating Network Motifs and Improving Microcircuit Manipulations in the Primate Hippocampus
The overall objective of this thesis is to elucidate previously unexplored nuances of hippocampal network communication while providing novel experimental and computational tools to motivate and enrich primate research. ... -
Examination of targeted, activity-dependent spinal stimulation in a rat model of spinal cord injury
Spinal cord injuries (SCIs) cause debilitating motor and sensory impairments that can significantly impact patients’ quality of life. Although an estimated 300,000 people in the United States are living with a spinal cord ... -
Facilitating the incorporation of neuroscience methods and knowledge into brain-computer interfaces
This body of work is focused on brain-computer interfaces (BCIs) – devices that interpret brain activity in order to generate artificial output. BCIs have a great deal of promise in both rehabilitative and commercial ... -
Fine-tuning Synaptic Plasticity by Modulation of Presynaptic CaV2.1 Channels with Ca2+ Sensor Proteins
(2013-02-25)Short-term plasticity of synaptic transmission is recognized as an important component of information processing in neuronal networks. Repetitive firing in neurons either leads to an increase, or to a decrease in synaptic ... -
Fly, Robot: The use of a controllable fly robot to explore object recognition and visual tracking during courtship in Drosophila
Though the application of genetic approaches has greatly increased our understanding of motion vision in the fruit fly, Drosophila melanogaster, little is known about higher-order functions of the visual system such as ... -
Form and Function of S-cone Opponent Circuits in the Primate Retina
Visual information is carried from the retina by the axons of >20 ganglion cell types, which project throughout the brain. While many of these parallel pathways are cone-opponent, not all the color information leaving the ... -
Form and function of the secondary hemilineages in the adult Drosophila thoracic nervous system
(2013-02-25)The majority of the neurons in the adult Drosophila thoracic nervous system are produced by one unpaired and twenty-four bilaterally paired, segmentally reiterated neuroblasts (NBs). Each neuroblast divides repeatedly, ... -
Fundamental Studies of Mouse Amacrine Cells
(2013-07-25)Vision begins in the retina where information about the salient features of an image projected on a mosaic of rod and cone photoreceptors is extracted and digitally encoded in neural impulses that are conducted by the axons ... -
Genetic and Functional Cartography of the Central Amygdala
The central nervous system includes an array of neuronal types classified across multiple features. Genetic dissection of the lateral division of the central amygdala (CeAl) has revealed two functionally distinct neuronal ... -
Genetic disruption of circadian rhythms impairs hippocampus-dependent memory
Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system. We ...