Browsing Neuroscience by Title
Now showing items 44-63 of 117
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Genetic and Functional Cartography of the Central Amygdala
The central nervous system includes an array of neuronal types classified across multiple features. Genetic dissection of the lateral division of the central amygdala (CeAl) has revealed two functionally distinct neuronal ... -
Genetic disruption of circadian rhythms impairs hippocampus-dependent memory
Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system. We ... -
The Genetic Identification and Physiological Characterization of a Novel Locus for Non-Progressive Hearing Loss on Mouse Chromosome 17
Presbycusis, the progressive loss of hearing that occurs with aging, is a widespread condition with serious economical and social ramifications. Mice with age-related hearing loss (AHL) are commonly used as models of ... -
Global and subtype-specific roles of GABAergic interneurons in Leigh syndrome related epilepsy
Leigh syndrome (LS), the most common mitochondrial disease in children, is caused by recessive, loss-of-function mutations in genes that encode for proteins within the mitochondria. Mutations associated with complex I (CI) ... -
Hair Cell Regeneration in the Crista Ampullaris of the Mammalian Vestibular System
The sensory modalities of hearing and balance are mediated by the six sensory organs of the inner ear that are each comprised of the same two main cell types, support cells and mechanosensory hair cells. Loss of the sensory ... -
Hippocampal and prefrontal regulation of flexible decision updating during memory-guided learning and decision-making
Decision-making requires us to integrate information that is spread out across timescales ranging from milliseconds to years. The information we use to guide decisions depends on current goals and the context in which the ... -
hiPSC-derived Neural Stem/Progenitor Cells in Chronic Cervical Spinal Cord Injury
(2013-02-25)hiPSCs have the potential to provide plentiful autologous cells for clinical translation to spinal cord injury, but substantial hurdles remain. The necessary conditions for effective cell replacement and plasticity to occur ... -
Hormonal Modulation of Auditory Processing in a Seasonally Breeding Songbird
(2013-07-23)Sex steroid hormones modulate vocal communication in a number of species. While much is known about the impact of these hormones on the motor systems responsible for generating vocal output, less is known about the influence ... -
HSD2 neurons and the neural circuitry underlying sodium appetite
Maintaining sodium homeostasis is critical for survival and is regulated by both dietary ingestion of salt and retention of sodium by the kidney. Beyond the hedonic aspects of sodium intake, animals will develop a voracious ... -
The Impact of Repeated Stress on Neuropeptidergic Regulation of Monoamine Systems
(2013-02-25)To promote an organism's evolutionary fitness, neurocircuitry has developed that encodes and responds to stressors. Stress motivates appropriate responding to environmental challenges through a diverse array of mechanisms ... -
Incorporating neural response variability into models for neural coding
One of the primary challenges facing neuroscientists is understanding how information is represented in neural circuits. These representations provide insight into the computations performed by individual neurons and ... -
Investigating the Impact of Drug History and Cortical Circuitry on Substance Use and Decision-Making
While substance use is commonplace within the United States, a subset of users will develop a substance use disorder (SUD). SUDs are characterized by binge-like intake with compulsive seeking and consumption, even in the ... -
Kappa Opioid Regulation of Dopamine in Dysphoria and Addiction
Stress-induced release of dynorphin and subsequent activation of the kappa opioid receptor (KOR) has been hypothesized to mediate the dysphoric component of stress. Evidence suggests that this dysphoria can alternately ... -
Kappa Opioid Regulation of Dopamine in Dysphoria and Addiction
Stress-induced release of dynorphin and subsequent activation of the kappa opioid receptor (KOR) has been hypothesized to mediate the dysphoric component of stress. Evidence suggests that this dysphoria can alternately ... -
Kindling Dravet Syndrome Symptoms from the Hippocampus
Dravet Syndrome is an epileptic condition with varied comorbidities caused by haploinsufficiency of the Scn1a gene, which encodes the alpha-1 subunit of the NaV1.1 sodium channel. Dravet Syndrome is characterized by ... -
Kinematics and sensorimotor control of walking in fruit flies
Animals move with remarkable agility, fluidly adjusting their limbs as they seamlesslymove from one behavior to another. Although the movements may look effortless, they are generated by complex feedback circuits which ... -
Mapping cellular and synaptic distributions in the mouse retina
The first step in perception occurs within the circuits of an organism's sensory systems. Throughout many sensory modalities, diverse arrays of neurons are often spatially organized to sample salient features and/or regions ... -
Mechanisms and treatments of drug consumption: A preclinical exploration in harm reducing pharmacotherapies for substance use disorders
The loss of control in amounts of drug consumed is a common trait experienced by persons living with drug addiction. The motivation of this dissertation is to further our understanding in the neural mechanisms that mediate ... -
Mechanosensory hair cell regeneration in the zebrafish lateral line is mitotic and facilitated by innervation
(2013-02-25)Mechanosensory hair cells in the inner ear are vulnerable to damage that can result in hearing loss and balance disorders. Exposure to excessive noise and ototoxic drugs are two of the leading causes of hair cell loss, ... -
Mesolimbic dopamine transmission during decisions involving cost-benefit tradeoffs
Real-world decisions frequently involve tradeoffs between multiple economic dimensions, and the integration of benefits and costs into a common currency of subjective value is fundamental to action selection. Phasic dopamine ...